Preparation of new complexes of anticipated biological activities

الملخص EN

Novel complexes of biological important activity were prepared by coordination of Mn(II) or Cr(II) metals with the ligand of Aspirin and Paracetamole mixture L = Aspirine(Asp) and Paracetamole(Parac) in 1:1:1 for the former and 1:1:2 molar ratio for the later.

The metal ions were tetrahedral and octahedral bonded to the ligand in the complexes respectively.

Aspirin coordinate through the carbonyl oxygen of the carboxyl and the ester groups, while paracetamol coordinate through the oxygen of the hydroxyl and the amide groups Complexes have been synthesized by conventional direct reaction in neutral medium and the products have the general formula [M(Asp/ Par]Cl 2 and [M 2 (Asp) 2 / (Par) 2 ]Cl 2 respectively.

Physical measurements including IR and UV / Visible spectra, CHN analysis and molar conductivity measurements showed these geometries around the metals.

The geometry (three dimensional structure) of complex (I and V) as representative of these complexes at minimized energy was established by chem.3D Ultra; molecular modeling and analysis confirmed the suggested structure tetrahedral and octahedral.