The effect of hemodialysis on lipid profile in Yemeni patients with chronic kidney disease

الملخص EN

Mortality from cardiovascular (CVD) disease in patients on chronic hemodialysis (CHD) is 10 to 20 times greater than in the general population.

Fifty Yemeni hemodialysis patients with end stage-renal disease (ESRD), aged 12-80 years, undergoing MHD at a dialysis Unit in Al-Thawra Hospital in Ibb city, were enrolled in this study.

Pre- and post-dialysis blood samples were collected and analyzed for plasma glucose, total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and triglycerides (TG).

Low density lipoprotein cholesterol (LDL-C) was determined by using the friedewald equation.

Non-HDL-C was calculated as TC-HDL-C.

Level of glucose was decreased significantly (P<0.05) by 51% post-dialysis.

There were significant post-dialysis increases in TC, LDL-C, non-HDL-C and TG by 39%, 45%, 52.3%, and 16.7% respectively, and also significant increases in antiatherogenic profile represented by HDL-C by about 14.7%.

In conclusion, levels of atherogenic lipoproteins increase postdialysis in Yemeni patients with ESRD.

The increase in lipid levels is therefore related to retention of lipoproteins with each dialysis.

With repeated dialysis, dyslipidaemia may get progressively worse and further accentuate Cardiovascular disease risk