IL-18 gene polymorphisms impacts on its serum levels in prostate cancer Iraqi patients
العناوين الأخرى
تأثير تعدد الإشكال الوراثي للحركي الخلوي-18 على مستواه في مصل دم مرضى سرطان البروستات العراقيين
المؤلفون المشاركون
Shukayr, Mahmud Talib
Utba, Nawal Muhammad
المصدر
العدد
المجلد 60، العدد 6 (30 يونيو/حزيران 2019)، ص ص. 1188-1196، 9ص.
الناشر
تاريخ النشر
2019-06-30
دولة النشر
العراق
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Prostate cancer is one of the most common types of cancer in men.
A total of 110 Iraqi Arab individuals were included in this study; 60 individuals of them had prostate cancer with increased levels of TPSA (patients group); their age range 52-90 years.
They were referred for diagnosis and treatment to the National Al-Amal Hospital for oncology in Baghdad during the period from July 2017 to October 2017.
While the other 50 apparently healthy subjects were the control group, their age range similar to patients group.
Sera and blood samples were collected from all patients and controls than used to assess for the level of IL-18 and DNA extraction, respectively.
The polymorphisms were analyzed using polymerase chain reaction-single specific primer (PCR-SSP), at the position -137 G\C (rs187238) in the promoter of IL18 gene.
The genetic polymorphism of the IL18 gene promoter -137G/C (rs187238) was determined and presented with three genotypes (GG, GC, and CC) in prostate cancer patients and controls.
Testing for Hardy-Weinberg (H-W) equilibrium revealed that Prostate cancer patients showed insignificant variation in the distribution of IL-18 -137 genotypes (P> 0.05).
While the control samples showed significant variation (p ≤0.05) between the observed and expected.
Comparing patients with controls indicated that IL-18-137 alleles or genotypes showed no association with the risk of prostate cancer development in Iraqi Arab population or protection against them.
Serum level of IL-18 was highly significant (P ≤ 0.001) increased in patients compared to control.
The IL-18 serum levels differences in GG and GC genotypes was significant (p <0.05) between patients and control.
While there were no significant differences between the three IL-18 -137 genotypes inpatient or in controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shukayr, Mahmud Talib& Utba, Nawal Muhammad. 2019. IL-18 gene polymorphisms impacts on its serum levels in prostate cancer Iraqi patients. Iraqi Journal of Science،Vol. 60, no. 6, pp.1188-1196.
https://search.emarefa.net/detail/BIM-969338
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shukayr, Mahmud Talib& Utba, Nawal Muhammad. IL-18 gene polymorphisms impacts on its serum levels in prostate cancer Iraqi patients. Iraqi Journal of Science Vol. 60, no. 6 (2019), pp.1188-1196.
https://search.emarefa.net/detail/BIM-969338
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shukayr, Mahmud Talib& Utba, Nawal Muhammad. IL-18 gene polymorphisms impacts on its serum levels in prostate cancer Iraqi patients. Iraqi Journal of Science. 2019. Vol. 60, no. 6, pp.1188-1196.
https://search.emarefa.net/detail/BIM-969338
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Text in English ; abstracts in English and Arabic.
رقم السجل
BIM-969338
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر