Study the effect of sulfanilamie and vitamin E on some biochemical and hematological parameters in adult male rabbits

الملخص EN

This study was designed to investigate the impact of sulfanilamide and sulfanilamide combined with vitamin E on - some biochemical and hematological parameters in adult male rabbits, this experiment was carried out on 18 male rabbits of (1000-1600 gm) were used in this study, these animal were adapted for one week before then were split into three groups (6 rabbits in each).

First group as control group were given of dimethyl sulphoxide (DMSO 0.

5 ml) I.

P daily, second group were treated with sulfanilamide drug (195 mg/kg) I.

P daily, however third group were given of sulfanilamide drug (195 mg/kg) I.

P and were administered orally vitamin E (0.

15 ml/kg) daily.

The treatment continues for three weeks, the results showed in the treated with sulfanilamide significantly reduction in RBCs, Hb, PCV, this reduction was companied by a significant decrease in MCH, MCHC, as well as a significant decrease in total WBCs and Platelet count, while were observed a significant increase in total cholesterol, triglyceride, LDL, VLDL associated with the a significant decrease in HDL, also, significantly elevation in serum AST and ALT levels, the study produced significantly reduction in total protein and albumin and a significant elevation in globulin in male rabbits treated with sulfanilamide, from our results the group treated with sulfanilamide and vitamin E showed improvement in hematological and biochemical parameters, It was concluded that administration of sulfanilamide caused several adverse effects while administration of vitamin E with sulfanilamide attenuation of this impact and get them close to its normal value.