Effect of some strains of lactic acid bacteria and their mixture on the biochemical traits of liver and thyroid gland in male rats with hypothyroidism induced using carbimazole

الملخص EN

The current study aims to use different strains of lactic acid bacteria in the treatment of thyroid diseases, Fortified milk containing the selected bacterial isolates L.

Plantarum, L.

caseiandL.

acidophilus and their mixture were used in a dose of 104 experimental animals of 117 male albino rats aged 9-12 weeks at an average weight of 23 g with induced hypothyroidism at a concentration of 0.6 g of carbimazole.1000g-1 rat weight , while control treatment (13 mice) was drank liquid milk only.

After the experiment was completed, blood samples were drawn to estimate the efficacy of liver enzymes Glutamate Oxaloacetate Transfer ease (GOT) and Glutamine Pyruvate Transferees (GPT), in addition to estimating thyroid hormones that included (Tryiodotheronin and Tetraiodothyronin) and Thyroid Stimulating Hormone (TSH).

In addition, microscopic examination of tissue sections was token from the thyroid gland.

The results of the study showed a significant increase in the level of liver enzymes in the group of mice affected with hypothyroidism induced by carbimazole compared to the control sample, and its return to significant increase when feeding with liquid milk containing bacteria under study and its mixture with a significant increase in the level of thyroid hormones triiodothyronine (T3) and Thyroxine (T4) and a significant decrease in the level of (TSH) when feeding with milk fortified with lactic acid bacteria.

The results of the histological study of thyroid sections showed that treatment with carbimazole and hypothyroidism led to degenerative changes in thyroid follicle cells and loss of cellular coordination with infiltration of inflammatory cells, bleaching of colloid, and hyperplasia in thyroid follicles.