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Impact of chronic Hepatitis B virus infection on bone mineral density
المؤلفون المشاركون
al-Maliki, Maysaa K.
al-Husayni, Istabraq Akram
al-Sammak, Maytham A.
Abu al-Hurr, Fahimah J.
المصدر
العدد
المجلد 17، العدد 3 (30 سبتمبر/أيلول 2020)، ص ص. 292-296، 5ص.
الناشر
تاريخ النشر
2020-09-30
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Chronic hepatitis B virus (HBV) infection is a common health problem that has a worldwide distribution.
Apart from the direct effect of the virus on the liver, there are many extrahepatic manifestations among which the probable effect on bone turnover associated with low bone mineral density (BMD).
Objectives : This study aimed to determine the association between treated and untreated chronic HBV infection with BMD.
Methods : This is a cross‑sectional study which included a total of 48 patients with chronic HBV (28 patients treated with tenofovir‑disoproxil‑fumarate [TDF] antiviral drug and 20 patients have not yet started treatment).
Other age‑.and sex‑matched 30 apparently healthy individuals were recruited to represent the healthy controls.
BMD was measured using dual‑energy X‑ray absorptiometry on the anteroposterior lumbar spine (L1–L4 spine) views, from which T‑score was calculated.
Liver function tests were also evaluated from serum samples.
Results: Treated patients showed a lower T‑score (− 0.48 ± 0.72) than either healthy individuals (1.08 ± 0.84) or untreated patients (0.78 ± 0.51), with highly significant differences.
In multivariate regression, only disease duration (adjusted odds ratio [OR] = 9.71, 95 % confidence interval [CI] = 4.8–16.68) and TDF treatment (adjusted OR = 6.4, 95 % CI = 4.18–97.05) were significantly associated with BMD.
Conclusions : Prolonged use of TDF in the treatment of HBV infection can significantly reduce BMD.
Moreover, BMD can also be inversely affected in long‑standing HBV, regardless of treatment regimen.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Husayni, Istabraq Akram& al-Maliki, Maysaa K.& al-Sammak, Maytham A.& Abu al-Hurr, Fahimah J.. 2020. Impact of chronic Hepatitis B virus infection on bone mineral density. Medical Journal of Babylon،Vol. 17, no. 3, pp.292-296.
https://search.emarefa.net/detail/BIM-975958
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Husayni, Istabraq Akram…[et al.]. Impact of chronic Hepatitis B virus infection on bone mineral density. Medical Journal of Babylon Vol. 17, no. 3 (Jul. / Sep. 2020), pp.292-296.
https://search.emarefa.net/detail/BIM-975958
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Husayni, Istabraq Akram& al-Maliki, Maysaa K.& al-Sammak, Maytham A.& Abu al-Hurr, Fahimah J.. Impact of chronic Hepatitis B virus infection on bone mineral density. Medical Journal of Babylon. 2020. Vol. 17, no. 3, pp.292-296.
https://search.emarefa.net/detail/BIM-975958
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Text in English ; abstracts in .
رقم السجل
BIM-975958
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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