A study of interleukin-18 (IL18) and high sensitive C-reactive protein (CRP) in type 2 diabetes (T2D) with or without obesity
المؤلفون المشاركون
Abd Allah, Amani M.
Kamil, Wahiba A.
al-Baz, Wala Fahmi
al-Baz, Wala Fahmi
المصدر
Arab Journal of Nuclear Sciences and Applications
العدد
المجلد 53، العدد 2 (30 إبريل/نيسان 2020)، ص ص. 36-45، 10ص.
الناشر
الجمعية المصرية للعلوم النووية و تطبيقاتها
تاريخ النشر
2020-04-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Both diabetes and obesity are associated with chronic low-grade inflammation.
IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions.
It is elevated in obesity, metabolic syndrome and type 2 diabetes (T2D).
Aim of study: to test the hypothesis that serum level of IL-18 and high sensitive C-reactive protein can be used as markers for presence of chronic low-grade inflammation in type 2 diabetes more than in obesity per se.
Subjects and methods: The study recruited 80 subjects.
They comprised 20 diabetic obese cases (DM-OB group), 20 diabetic non-obese cases (DM-NOB group), : 20 non-diabetic obese cases (NDM-OB group) and 20 non-diabetic non-obese subjects (NDM-NOB group).
All participants were submitted to careful history taking, through clinical investigations and laboratory assessment
Results: hs-CRP was significantly highest in DMOB group (3.4±0.5 mg/dl) followed by NDM-OB group (2.9±0.4 mg/dl) followed by DM-NOB group (2.3±0.3 mg/dl) and least in NDM-NOB (0.8±0.3 mg/dl).
Also, it was found that serum IL-18 was significantly highest in DMOB group (397.8±33.9 pg/mL) followed by NDM-OB (368.8±26.7 pg/mL) group followed by DM-NOB group (335.9±18.4 pg/mL) and least in NDM-NOB group (281.1±22.9 pg/mL).
Serum IL-18 levels are directly correlated with BMI, waist circumference, hip circumference and waist/hip ratio in all the studied groups and with HbA1c in the diabetic groups.
Conclusions: Serum IL-18 and hs-CRP are related to diabetes and obesity.
They are associated with dyslipidemia, poor glycemic control, insulin resistance and impaired liver and renal functions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kamil, Wahiba A.& al-Baz, Wala Fahmi& Abd Allah, Amani M.& al-Baz, Wala Fahmi& al-Najjar, Abir H.. 2020. A study of interleukin-18 (IL18) and high sensitive C-reactive protein (CRP) in type 2 diabetes (T2D) with or without obesity. Arab Journal of Nuclear Sciences and Applications،Vol. 53, no. 2, pp.36-45.
https://search.emarefa.net/detail/BIM-980028
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Najjar, Abir H.…[et al.]. A study of interleukin-18 (IL18) and high sensitive C-reactive protein (CRP) in type 2 diabetes (T2D) with or without obesity. Arab Journal of Nuclear Sciences and Applications Vol. 53, no. 2 (2020), pp.36-45.
https://search.emarefa.net/detail/BIM-980028
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kamil, Wahiba A.& al-Baz, Wala Fahmi& Abd Allah, Amani M.& al-Baz, Wala Fahmi& al-Najjar, Abir H.. A study of interleukin-18 (IL18) and high sensitive C-reactive protein (CRP) in type 2 diabetes (T2D) with or without obesity. Arab Journal of Nuclear Sciences and Applications. 2020. Vol. 53, no. 2, pp.36-45.
https://search.emarefa.net/detail/BIM-980028
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 43-45
رقم السجل
BIM-980028
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر