Evaluation of Anti-HIV-1 Integrase and Anti-Inflammatory Activities of Compounds from Betula alnoides Buch-Ham
المؤلفون المشاركون
Chaniad, Prapaporn
Sudsai, Teeratad
Septama, Abdi Wira
Chukaew, Arnon
Tewtrakul, Supinya
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Betula alnoides is a medicinal plant in Thai traditional longevity preparations.
The crude extracts of this plant possess various biological activities.
However, the isolated compounds from this plant have no reports of anti-HIV-1 integrase (IN) activity.
Therefore, the present study aims to investigate the anti-HIV-1 integrase and anti-inflammatory effects of isolated compounds from this plant and predict the interaction of compounds with integrase active sites.
From the bioassay-guided fractionation of the ethanol extract of B.
alnoides stems using chromatographic techniques, five pentacyclic triterpenoid compounds were obtained.
They are betulinic acid (1), betulin (2), lupeol (3), oleanolic acid (4), and ursolic acid (5).
Compound 2 exhibited the most potent inhibitory activity against HIV-1 IN, with an IC50 value of 17.7 μM.
Potential interactions of compounds with IN active sites were investigated using computational docking.
The results indicated that active compounds interacted with Asp64, a residue participating in 3′-processing, and Thr66, His67, and Lys159, residues participating in strand-transfer reactions of the integration process.
Regarding anti-inflammatory activity, all compounds exerted significant inhibitory effects on LPS-induced nitric oxide production (IC50 < 68.7 μM).
Thus, this research provides additional scientific support for the use of B.
alnoides in traditional medicine for the treatment of HIV patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chaniad, Prapaporn& Sudsai, Teeratad& Septama, Abdi Wira& Chukaew, Arnon& Tewtrakul, Supinya. 2019. Evaluation of Anti-HIV-1 Integrase and Anti-Inflammatory Activities of Compounds from Betula alnoides Buch-Ham. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-986290
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chaniad, Prapaporn…[et al.]. Evaluation of Anti-HIV-1 Integrase and Anti-Inflammatory Activities of Compounds from Betula alnoides Buch-Ham. Advances in Pharmacological and Pharmaceutical Sciences No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-986290
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chaniad, Prapaporn& Sudsai, Teeratad& Septama, Abdi Wira& Chukaew, Arnon& Tewtrakul, Supinya. Evaluation of Anti-HIV-1 Integrase and Anti-Inflammatory Activities of Compounds from Betula alnoides Buch-Ham. Advances in Pharmacological and Pharmaceutical Sciences. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-986290
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-986290
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر