Allergic Airway-Induced Hypersensitivity Is Attenuated by Bergapten in Murine Models of Inflammation

المؤلفون المشاركون

Aidoo, Douglas B.
Obiri, David D.
Osafo, Newman
Antwi, Aaron O.
Essel, Leslie B.
Duduyemi, Babatunde M.
Ekor, Martins

المصدر

Advances in Pharmacological and Pharmaceutical Sciences

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-02-03

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

علم الصيدلة

الملخص EN

Bergapten (5-methoxypsoralen, 5-MOP) is a plant-derived furocoumarin with demonstrated anti-inflammatory action.

The present study investigated its effects on allergic inflammation in two related pathways of mast cell degranulation.

Compound 48/80 and lipopolysaccharide (LPS) were used to activate the IgE-independent pathway while bovine serum albumin (BSA) was used as allergen for the IgE-dependent pathway.

The modulatory effect of bergapten on mast cell degranulation, neutrophil extravasation, protein concentration, lung histopathology, and oxidative stress was assessed.

Bergapten at 10, 30, and 100 μg/ml for 15 min stabilized mast cells in rat mesenteric tissue from disruption in vitro and when administered in vivo at 3, 10, and 30 mg kg−1 for 1 h protected mice from fatal anaphylaxis induced by compound 48/80.

Similarly, treatment of LPS-challenged mice with bergapten (3, 10, and 30 mg kg−1) for 24 h significantly decreased neutrophil infiltration into bronchoalveolar lavage fluid, mean protein concentration, and inflammatory cell infiltration of pulmonary tissues when compared to the saline-treated LPS-challenged control.

In addition, lung histology of the bergapten-treated LPS-challenged mice showed significantly less oedema, congestion, and alveolar septa thickening when compared to the saline-treated LPS-challenged disease control.

LPS-induced oxidative stress was significantly reduced through increased tissue activities of catalase and superoxide dismutase and reduced malondialdehyde levels on treatment with bergapten.

In the triple antigen-induced active anaphylaxis, daily administration of bergapten at 3, 10, and 30 mg kg−1 for 10 days, respectively, protected previously sensitized and challenged mice against anaphylactic shock.

Overall, our study demonstrates the ability of bergapten to attenuate allergic airway-induced hypersensitivity in murine models of inflammation, suggesting its possible therapeutic benefit in this condition.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Aidoo, Douglas B.& Obiri, David D.& Osafo, Newman& Antwi, Aaron O.& Essel, Leslie B.& Duduyemi, Babatunde M.…[et al.]. 2019. Allergic Airway-Induced Hypersensitivity Is Attenuated by Bergapten in Murine Models of Inflammation. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-986299

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Aidoo, Douglas B.…[et al.]. Allergic Airway-Induced Hypersensitivity Is Attenuated by Bergapten in Murine Models of Inflammation. Advances in Pharmacological and Pharmaceutical Sciences No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-986299

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Aidoo, Douglas B.& Obiri, David D.& Osafo, Newman& Antwi, Aaron O.& Essel, Leslie B.& Duduyemi, Babatunde M.…[et al.]. Allergic Airway-Induced Hypersensitivity Is Attenuated by Bergapten in Murine Models of Inflammation. Advances in Pharmacological and Pharmaceutical Sciences. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-986299

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-986299