Differential Induction of Long-Term Potentiation in the Horizontal versus Columnar Superficial Connections to Layer II Cells of the Entorhinal Cortex
المؤلفون المشاركون
Ma, Li
Alonso, Angel
Dickson, Clayton T.
المصدر
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-06-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The entorhinal cortex (EC) is a nodal and independent mnemonic element of the medial temporal lobe memory circuit as it forms a bidirectional interface between the neocortex and hippocampus.
Within the EC, intra- and inter-lamellar associational connections occur via horizontal and columnar projections, respectively.
We undertook a comparative study of these two inputs as they converge upon EC layer II cells using whole-cell patch techniques in an adult rat EC horizontal slice preparation in which the deepest layers (V-VI) had been dissected out.
Electrical stimulation of layers I and III during GABA blockade allowed us to study excitatory synaptic properties and plasticity in the horizontal and columnar fibre systems, respectively.
Both pathways exhibited AMPA- and NMDA-receptor mediated transmission and both exhibited long-term potentiation (LTP) after high-frequency (tetanic) stimulation.
LTP in the horizontal, but not in the columnar pathway, was blocked by NMDA receptor antagonism.
Intriguingly, LTP in both appeared to be mediated by post synaptic increases in Ca2+ that may be coupled to differing second messenger pathways.
Thus, the superficial excitatory horizontal and columnar associative pathways to layer II have divergent mechanisms for LTP which may endow the EC with even more complex and dynamic processing characteristics than previously thought.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Li& Alonso, Angel& Dickson, Clayton T.. 2008. Differential Induction of Long-Term Potentiation in the Horizontal versus Columnar Superficial Connections to Layer II Cells of the Entorhinal Cortex. Neural Plasticity،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988159
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Li…[et al.]. Differential Induction of Long-Term Potentiation in the Horizontal versus Columnar Superficial Connections to Layer II Cells of the Entorhinal Cortex. Neural Plasticity No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-988159
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Li& Alonso, Angel& Dickson, Clayton T.. Differential Induction of Long-Term Potentiation in the Horizontal versus Columnar Superficial Connections to Layer II Cells of the Entorhinal Cortex. Neural Plasticity. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-988159
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-988159
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر