p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway

المؤلفون المشاركون

Song, Yang
Liang, Xianmin
Cheng, Jin
Guan, Xia
Wang, Yinan
Hu, Yafei
Yang, Kedi
Shi, Yuqin

المصدر

BioMed Research International

العدد

المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2009-06-28

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الطب البشري

الملخص EN

One,1-dichloro-2,2 bis(p-chlorophenyl) ethylene (p,p′-DDE), the major metabolite of 2,2-bis(4-Chlorophenyl)-1,1,1-trichloroethane (DDT), is a known persistent organic pollutant and male reproductive toxicant.

It has antiandrogenic effect.

However, the mechanism by which p,p′-DDE exposure causes male reproductive toxicity remains unknown.

In the present study, rat Sertoli cells were used to investigate the molecular mechanism involved in p,p′-DDE-induced toxicity in male reproductive system.

The results indicated that p,p′-DDE exposure at over 30 μM showed the induction of apoptotic cell death.

p,p′-DDE could induce increases in FasL mRNA and protein, which could be blocked by an antioxidant agent, N-acetyl-l-cysteine (NAC).

In addition, caspase-3 and -8 were activated by p,p′-DDE treatment in these cells.

The activation of NF-κB was enhanced with the increase of p,p′-DDE dose.

Taken together, these results suggested that exposure to p,p′-DDE might induce apoptosis of rat Sertoli cells through a FasL-dependent pathway.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Shi, Yuqin& Song, Yang& Wang, Yinan& Liang, Xianmin& Hu, Yafei& Guan, Xia…[et al.]. 2009. p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway. BioMed Research International،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-988334

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Shi, Yuqin…[et al.]. p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway. BioMed Research International No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-988334

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Shi, Yuqin& Song, Yang& Wang, Yinan& Liang, Xianmin& Hu, Yafei& Guan, Xia…[et al.]. p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-988334

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-988334