p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway
Joint Authors
Song, Yang
Liang, Xianmin
Cheng, Jin
Guan, Xia
Wang, Yinan
Hu, Yafei
Yang, Kedi
Shi, Yuqin
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
One,1-dichloro-2,2 bis(p-chlorophenyl) ethylene (p,p′-DDE), the major metabolite of 2,2-bis(4-Chlorophenyl)-1,1,1-trichloroethane (DDT), is a known persistent organic pollutant and male reproductive toxicant.
It has antiandrogenic effect.
However, the mechanism by which p,p′-DDE exposure causes male reproductive toxicity remains unknown.
In the present study, rat Sertoli cells were used to investigate the molecular mechanism involved in p,p′-DDE-induced toxicity in male reproductive system.
The results indicated that p,p′-DDE exposure at over 30 μM showed the induction of apoptotic cell death.
p,p′-DDE could induce increases in FasL mRNA and protein, which could be blocked by an antioxidant agent, N-acetyl-l-cysteine (NAC).
In addition, caspase-3 and -8 were activated by p,p′-DDE treatment in these cells.
The activation of NF-κB was enhanced with the increase of p,p′-DDE dose.
Taken together, these results suggested that exposure to p,p′-DDE might induce apoptosis of rat Sertoli cells through a FasL-dependent pathway.
American Psychological Association (APA)
Shi, Yuqin& Song, Yang& Wang, Yinan& Liang, Xianmin& Hu, Yafei& Guan, Xia…[et al.]. 2009. p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway. BioMed Research International،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-988334
Modern Language Association (MLA)
Shi, Yuqin…[et al.]. p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway. BioMed Research International No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-988334
American Medical Association (AMA)
Shi, Yuqin& Song, Yang& Wang, Yinan& Liang, Xianmin& Hu, Yafei& Guan, Xia…[et al.]. p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-988334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988334