Low-Frequency Low-Intensity Ultrasounds Do Not Influence the Survival and Immune Functions of Cultured Keratinocytes and Dendritic Cells
المؤلفون المشاركون
De Pità, Ornella
Sestito, Rosanna
Pavani, Francesca
Albanesi, Cristina
Simonacci, Marco
Madonna, Stefania
Cavani, Andrea
Nasorri, Francesca
Scarponi, Claudia
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-12-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Low-frequency ultrasounds (US) are used to enhance drug transdermal transport.
Although this phenomenon has been extensively analyzed, information on US effects on the single skin cell components is limited.
Here, we investigated the possible effects of low-frequency US on viability and immune functions of cultured human keratinocytes and dendritic cells (DC), skin cells involved in the regulation of many immune-mediated dermatoses.
We demonstrated that US, employed at low-frequency (42 KHz) and low-intensity (0.15 W/cm2) values known to enhance drug and water transdermal transport, did not affect extracellular-signal-regulated-kinase (ERK)1/2 activation, cell viability, or expression of adhesion molecules in cultured keratinocytes.
Moreover, US at these work frequency and intensity did not influence the keratinocyte expression and release of immunomodulatory molecules.
Similarly, cultured DC treated with low-frequency low-intensity US were viable, and did not show an altered membrane phenotype, cytokine profile, nor antigen presentation ability.
However, intensity enhancement of low-frequency US to 5 W/cm2 determined an increase of the apoptotic rate of both keratinocytes and DC as well as keratinocyte CXCL8 release and ERK1/2 activation, and DC CD40 expression.
Our study sustains the employment of low-frequency and low-intensity US for treatment of those immune skin disorders, where keratinocytes and DC have a pathogenetic role.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Scarponi, Claudia& Nasorri, Francesca& Pavani, Francesca& Madonna, Stefania& Sestito, Rosanna& Simonacci, Marco…[et al.]. 2009. Low-Frequency Low-Intensity Ultrasounds Do Not Influence the Survival and Immune Functions of Cultured Keratinocytes and Dendritic Cells. BioMed Research International،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-988338
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Scarponi, Claudia…[et al.]. Low-Frequency Low-Intensity Ultrasounds Do Not Influence the Survival and Immune Functions of Cultured Keratinocytes and Dendritic Cells. BioMed Research International No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-988338
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Scarponi, Claudia& Nasorri, Francesca& Pavani, Francesca& Madonna, Stefania& Sestito, Rosanna& Simonacci, Marco…[et al.]. Low-Frequency Low-Intensity Ultrasounds Do Not Influence the Survival and Immune Functions of Cultured Keratinocytes and Dendritic Cells. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-988338
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-988338
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر