OXavidin for Tissue Targeting Biotinylated Therapeutics

المؤلفون المشاركون

De Santis, Rita
Albertoni, Claudio
Salvatori, Giovanni
Leoni, Barbara
Petronzelli, Fiorella
Paganelli, Giovanni
Verdoliva, Antonio
D'Alessio, Valeria
Nuzzolo, Carlo Antonio
Nucera, Eleonora
Rosi, Antonio
Carminati, Paolo

المصدر

BioMed Research International

العدد

المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-01-10

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Avidin is a glycoprotein from hen egg white that binds biotin with very high affinity.

Here we describe OXavidin, a product containing aldehyde groups, obtained by ligand-assisted sugar oxidation of avidin by sodium periodate.

OXavidin chemically reacts with cellular and tissue proteins through Schiff's base formation thus residing in tissues for weeks while preserving the biotin binding capacity.

The long tissue residence of OXavidin as well as that of OXavidin/biotinylated agent complex occurs in normal and neoplastic tissues and immunohistochemistry shows a strong and homogenous stromal localization.

Once localized in tissue/tumor, OXavidin becomes an “artificial receptor” for intravenous injected biotin allowing tumor targeting with biotinylated therapeutics like radioisotopes or toxins.

Moreover, present data also suggest that OXavidin might be useful for the homing of biotinylated cells.

Overall, OXavidin exhibits a remarkable potential for many different therapeutic applications.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

De Santis, Rita& Albertoni, Claudio& Rosi, Antonio& Leoni, Barbara& Petronzelli, Fiorella& D'Alessio, Valeria…[et al.]. 2010. OXavidin for Tissue Targeting Biotinylated Therapeutics. BioMed Research International،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988478

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

De Santis, Rita…[et al.]. OXavidin for Tissue Targeting Biotinylated Therapeutics. BioMed Research International No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-988478

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

De Santis, Rita& Albertoni, Claudio& Rosi, Antonio& Leoni, Barbara& Petronzelli, Fiorella& D'Alessio, Valeria…[et al.]. OXavidin for Tissue Targeting Biotinylated Therapeutics. BioMed Research International. 2010. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988478

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-988478