Association of Interleukin-8 with Cachexia from Patients with Low-Third Gastric Cancer
المؤلفون المشاركون
Song, Bo
Wang, Shuchun
Zhang, Dianliang
Wang, Xinxiang
Zheng, Hongmei
المصدر
International Journal of Genomics
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-10-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Interleukin (IL)-8 has been implicated in the development of cancer cachexia.
The polymorphism of IL-8 gene, which may affect the production level of IL-8, may be associated with cancer cachexia.
Methods.
The serum IL-8 level in our study was examined by radioimmunoassay.
We also analyzed single nucleotide polymorphisms (SNPs) −251 A/T and +781 C/T of IL-8 gene, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results.
The serum levels of IL-8 were significantly elevated in patients with low-third gastric cancer compared with controls, and were further up-regulated in patients with cachexia than those without (Z=−3.134, P=.002).
A significantly increased frequency of +781 T allele was noted in patients with cachexia (OR=2.247, 95% CI: 1.351–3.737, P=.002).
The +781 TT genotype was observed to be associated with a significantly increased risk of cachexia (OR=3.167, 95% CI: 1.265–7.929, P=.011), and with odds ratio of 3.033 (95% CI: 1.065–8.639, P=.038) for cachexia after adjusting for potential confounding factors.
Meanwhile, haplotype analysis indicated a borderline positive association between T251T781 haplotype and cachexia as compared with the T251C781 haplotype (OR=4.92, 95% CI: 1.00–24.28; ,P=.053).
Conclusions.
IL-8 appears to be associated with cachexia from patients with low-third gastric cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Bo& Zhang, Dianliang& Wang, Shuchun& Zheng, Hongmei& Wang, Xinxiang. 2009. Association of Interleukin-8 with Cachexia from Patients with Low-Third Gastric Cancer. International Journal of Genomics،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-988516
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Bo…[et al.]. Association of Interleukin-8 with Cachexia from Patients with Low-Third Gastric Cancer. International Journal of Genomics No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-988516
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Bo& Zhang, Dianliang& Wang, Shuchun& Zheng, Hongmei& Wang, Xinxiang. Association of Interleukin-8 with Cachexia from Patients with Low-Third Gastric Cancer. International Journal of Genomics. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-988516
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-988516
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر