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An Exon-Based Comparative Variant Analysis Pipeline to Study the Scale and Role of Frameshift and Nonsense Mutation in the Human-Chimpanzee Divergence
المؤلف
المصدر
International Journal of Genomics
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-09-09
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Chimpanzees and humans are closely related but differ in many deadly human diseases and other characteristics in physiology, anatomy, and pathology.
In spite of decades of extensive research, crucial questions about the molecular mechanisms behind the differences are yet to be understood.
Here I report ExonVar, a novel computational pipeline for Exon-based human-chimpanzee comparative Variant analysis.
The objective is to comparatively analyze mutations specifically those that caused the frameshift and nonsense mutations and to assess their scale and potential impacts on human-chimpanzee divergence.
Genomewide analysis of human and chimpanzee exons with ExonVar identified a number of species-specific, exon-disrupting mutations in chimpanzees but much fewer in humans.
Many were found on genes involved in important biological processes such as T cell lineage development, the pathogenesis of inflammatory diseases, and antigen induced cell death.
A “less-is-more” model was previously established to illustrate the role of the gene inactivation and disruptions during human evolution.
Here this analysis suggested a different model where the chimpanzee-specific exon-disrupting mutations may act as additional evolutionary force that drove the human-chimpanzee divergence.
Finally, the analysis revealed a number of sequencing errors in the chimpanzee and human genome sequences and further illustrated that they could be corrected without resequencing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, GongXin. 2009. An Exon-Based Comparative Variant Analysis Pipeline to Study the Scale and Role of Frameshift and Nonsense Mutation in the Human-Chimpanzee Divergence. International Journal of Genomics،Vol. 2009, no. 2009, pp.1-19.
https://search.emarefa.net/detail/BIM-988523
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, GongXin. An Exon-Based Comparative Variant Analysis Pipeline to Study the Scale and Role of Frameshift and Nonsense Mutation in the Human-Chimpanzee Divergence. International Journal of Genomics No. 2009 (2009), pp.1-19.
https://search.emarefa.net/detail/BIM-988523
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, GongXin. An Exon-Based Comparative Variant Analysis Pipeline to Study the Scale and Role of Frameshift and Nonsense Mutation in the Human-Chimpanzee Divergence. International Journal of Genomics. 2009. Vol. 2009, no. 2009, pp.1-19.
https://search.emarefa.net/detail/BIM-988523
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-988523
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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