Altered Regulation of Contraction-Induced AktmTORp70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat

المؤلفون المشاركون

Katta, Anjaiah
Rice, Kevin M.
Karkala, S. K.
Gadde, Murali K.
Wu, Miaozong
Kolli, Madhukar
Arvapalli, Ravikumar
Paturi, Satyanarayana
Blough, Eric R.

المصدر

Journal of Diabetes Research

العدد

المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-02-14

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Increased muscle loading results in the phosphorylation of the 70 kDa ribosomal S6 kinase (p70S6k), and this event is strongly correlated with the degree of muscle adaptation following resistance exercise.

Whether insulin resistance or the comorbidities associated with this disorder may affect the ability of skeletal muscle to activate p70S6k signaling following an exercise stimulus remains unclear.

Here, we compare the contraction-induced activation of p70S6k signaling in the plantaris muscles of lean and insulin resistant obese Zucker rats following a single bout of increased contractile loading.

Compared to lean animals, the basal phosphorylation of p70S6k (Thr389; 37.2% and Thr421/Ser424; 101.4%), Akt (Thr308; 25.1%), and mTOR (Ser2448; 63.0%) was higher in obese animals.

Contraction increased the phosphorylation of p70S6k (Thr389), Akt (Ser473), and mTOR (Ser2448) in both models however the magnitude and kinetics of activation differed between models.

These results suggest that contraction-induced activation of p70S6k signaling is altered in the muscle of the insulin resistant obese Zucker rat.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Katta, Anjaiah& Karkala, S. K.& Wu, Miaozong& Paturi, Satyanarayana& Gadde, Murali K.& Arvapalli, Ravikumar…[et al.]. 2010. Altered Regulation of Contraction-Induced AktmTORp70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat. Journal of Diabetes Research،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988576

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Katta, Anjaiah…[et al.]. Altered Regulation of Contraction-Induced AktmTORp70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat. Journal of Diabetes Research No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-988576

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Katta, Anjaiah& Karkala, S. K.& Wu, Miaozong& Paturi, Satyanarayana& Gadde, Murali K.& Arvapalli, Ravikumar…[et al.]. Altered Regulation of Contraction-Induced AktmTORp70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat. Journal of Diabetes Research. 2010. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988576

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-988576