Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes

المؤلفون المشاركون

Kamiya, Hideki
Zhang, Weixian
Sima, Anders A. F.

المصدر

Journal of Diabetes Research

العدد

المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2009-09-01

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

We investigated mechanisms underlying progressive axonal dysfunction and structural deficits in type 1 BB/Wor-rats from 1 week to 10 month diabetes duration.

Motor and sensory conduction velocities were decreased after 4 and 6 weeks of diabetes and declined further over the remaining 9 months.

Myelinated sural nerve fibers showed progressive deficits in fiber numbers and sizes.

Structural deficits in unmyelinated axonal size were evident at 2 month and deficits in number were present at 4 mo.

These changes were preceded by decreased availability of insulin, C-peptide and IGF-1 and decreased expression of neurofilaments and β-III-tubulin.

Upregulation of phosphorylating stress kinases like Cdk5, p-GSK-3β, and p42/44 resulted in increased phosphorylation of neurofilaments.

Increasing activity of p-GSK-3β correlated with increasing phosphorylation of NFH, whereas decreasing Cdk5 correlated with diminishing phosphorylation of NFM.

The data suggest that impaired neurotrophic support results in sequentially impaired synthesis and postranslational modifications of neuroskeletal proteins, resulting in progressive deficits in axonal function, maturation and size.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kamiya, Hideki& Zhang, Weixian& Sima, Anders A. F.. 2009. Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes. Journal of Diabetes Research،Vol. 2009, no. 2009, pp.1-14.
https://search.emarefa.net/detail/BIM-988585

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kamiya, Hideki…[et al.]. Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes. Journal of Diabetes Research No. 2009 (2009), pp.1-14.
https://search.emarefa.net/detail/BIM-988585

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kamiya, Hideki& Zhang, Weixian& Sima, Anders A. F.. Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes. Journal of Diabetes Research. 2009. Vol. 2009, no. 2009, pp.1-14.
https://search.emarefa.net/detail/BIM-988585

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-988585