![](/images/graphics-bg.png)
Testosterone and Cholesterol Vasodilation of Rat Aorta Involves L-Type Calcium Channel Inhibition
المؤلفون المشاركون
Verde, I.
Álvarez, E.
Morais, C.
Morgado, M.
Cairrão, E.
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-03-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Testosterone has rapid nongenomic vasodilator effects which could be involved in protective cardiovascular actions.
Several authors suggested specific mechanisms to explain this effect, but this matter was not clarified yet.
We studied the actions of testosterone and cholesterol on endothelium-denuded rat aorta and their effects on the L-type Ca2+ current (ICa,L) and potassium current (IK).
Testosterone (1–100 μM) totally relaxed, in a rapid and concentration-dependent way, the aortic rings contracted by KCl or by (−)-Bay K8644 (BAY).
Cholesterol also fully relaxed the contractions induced by KCl.
None of the potassium channel antagonists tested (glibenclamide, tetraethylammonium and 4-aminopyridine) modified significantly the relaxant effect of testosterone.
The antagonist of classic testosterone receptors, flutamide, did not modify the vasorelaxant effect of testosterone.
Furthermore, testosterone and cholesterol inhibited either basal and BAY-stimulated ICa,L in A7r5 cells and they have no effects on IK.
In summary, our results demonstrate that cholesterol and testosterone relax rat aorta by inhibiting LTCC.
This effect of testosterone is not mediated by the classic hormone receptor or by potassium channel activation.
These results suggest that the vasodilator mechanism of cholesterol and testosterone is the same.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Álvarez, E.& Cairrão, E.& Morgado, M.& Morais, C.& Verde, I.. 2010. Testosterone and Cholesterol Vasodilation of Rat Aorta Involves L-Type Calcium Channel Inhibition. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-988671
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Álvarez, E.…[et al.]. Testosterone and Cholesterol Vasodilation of Rat Aorta Involves L-Type Calcium Channel Inhibition. Advances in Pharmacological and Pharmaceutical Sciences No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-988671
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Álvarez, E.& Cairrão, E.& Morgado, M.& Morais, C.& Verde, I.. Testosterone and Cholesterol Vasodilation of Rat Aorta Involves L-Type Calcium Channel Inhibition. Advances in Pharmacological and Pharmaceutical Sciences. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-988671
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-988671
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)