Gene Expression Profiling of Placentas Affected by Pre-Eclampsia
المؤلفون المشاركون
Borup, Rehannah
Sørensen, Steen
Hviid, Thomas V. F.
Hoegh, Anne Mette
Nielsen, Finn Cilius
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-01-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Several studies point to the placenta as the primary cause of pre-eclampsia.
Our objective was to identify placental genes that may contribute to the development of pre-eclampsia.
RNA was purified from tissue biopsies from eleven pre-eclamptic placentas and eighteen normal controls.
Messenger RNA expression from pooled samples was analysed by microarrays.
Verification of the expression of selected genes was performed using real-time PCR.
A surprisingly low number of genes (21 out of 15,000) were identified as differentially expressed.
Among these were genes not previously associated with pre-eclampsia as bradykinin B1 receptor and a 14-3-3 protein, but also genes that have already been connected with pre-eclampsia, for example, inhibin beta A subunit and leptin.
A low number of genes were repeatedly identified as differentially expressed, because they may represent the endpoint of a cascade of events effectuated throughout gestation.
They were associated with transcriptional regulation and vasoregulative pathways, along with a number of hypothetical proteins and gene sequences with unknown functions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hoegh, Anne Mette& Borup, Rehannah& Nielsen, Finn Cilius& Sørensen, Steen& Hviid, Thomas V. F.. 2010. Gene Expression Profiling of Placentas Affected by Pre-Eclampsia. BioMed Research International،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989119
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hoegh, Anne Mette…[et al.]. Gene Expression Profiling of Placentas Affected by Pre-Eclampsia. BioMed Research International No. 2010 (Dec. 2010), pp.1-11.
https://search.emarefa.net/detail/BIM-989119
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hoegh, Anne Mette& Borup, Rehannah& Nielsen, Finn Cilius& Sørensen, Steen& Hviid, Thomas V. F.. Gene Expression Profiling of Placentas Affected by Pre-Eclampsia. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989119
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-989119
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر