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Glucose Regulation of Thrombospondin and Its Role in the Modulation of Smooth Muscle Cell Proliferation
المؤلفون المشاركون
Gollahon, Katherine A.
Allen, Lee B.
Clemmons, David R.
Dunbar, Paul
Maile, Laura A.
Hanzaker, Christopher F.
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-05-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Smooth muscle cells (SMC) maintained in high glucose are more responsive to IGF-I than those in normal glucose.
There is significantly more thrombospondin-1 (TSP-1) in extracellular matrix surrounding SMC grown in 25 mM glucose.
In this study we investigated 1) the mechanism by which glucose regulates TSP-1 levels and 2) the mechanism by which TS-1 enhances IGF-I signaling.
The addition of TSP-1 to primary SMC was sufficient to enhance IGF-I responsiveness in normal glucose.
Reducing TSP-1 protein levels inhibited IGF-I signaling in SMC maintained in high glucose.
We determined that TSP-1 protected IAP/CD47 from cleavage and thereby facilitated its association with SHP substrate-1 (SHPS-1).
We have shown previously that the hyperglycemia induced protection of IAP from cleavage is an important component of the ability of hyperglycemia to enhance IGF-I signaling.
Furthermore we determined that TSP-1 also enhanced phosphorylation of the β3 subunit of the αVβ3 integrin, another molecular event that we have shown are critical for SMC response to IGF-I in high glucose.
Our studies also revealed that the difference in the amount of TSP-1 in the two different glucose conditions was due, at least in part, to a difference in the cellular uptake and degradation of TSP-1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maile, Laura A.& Allen, Lee B.& Hanzaker, Christopher F.& Gollahon, Katherine A.& Dunbar, Paul& Clemmons, David R.. 2010. Glucose Regulation of Thrombospondin and Its Role in the Modulation of Smooth Muscle Cell Proliferation. Journal of Diabetes Research،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989275
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maile, Laura A.…[et al.]. Glucose Regulation of Thrombospondin and Its Role in the Modulation of Smooth Muscle Cell Proliferation. Journal of Diabetes Research No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-989275
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maile, Laura A.& Allen, Lee B.& Hanzaker, Christopher F.& Gollahon, Katherine A.& Dunbar, Paul& Clemmons, David R.. Glucose Regulation of Thrombospondin and Its Role in the Modulation of Smooth Muscle Cell Proliferation. Journal of Diabetes Research. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989275
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-989275
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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