Cytokines and Metabolic Patterns in Pediatric Patients with Critical Illness
المؤلفون المشاركون
Briassoulis, George
Thompson, Ann
Venkataraman, Shekhar
المصدر
Journal of Immunology Research
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-04-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
It is not known if cytokines, which are cell-derived mediators released during the host immune response to stress, affect metabolic response to stress during critical illness.
The aim of this prospective study was to determine whether the metabolic response to stress is related to the inflammatory interleukin-6 (IL-6), 10 (IL-10), and other stress mediators' responses and to assess their relationships with different feeding patterns, nutritional markers, the severity of illness as assessed by the Multiple Organ System Failure (MOSF), the Pediatric Risk of Mortality Score (PRISM), systemic inflammatory response syndrome (SIRS), and mortality in critically ill children.
Patients were classified as hypermetabolic, normometabolic, and hypometabolic when the measured resting energy expenditures (REE) were >110%, 90–110% and, <90% of the predicted basal metabolic rate, respectively.
The initial predominance of the hypometabolic pattern (48.6%) declined within 1 week of acute stress (20%), and the hypermetabolic patterns dominated only after 2 weeks (60%).
Only oxygen consumption (VO2) and carbon dioxide production (VCO2) (P<.0001) but none of the cytokines and nutritional markers, were independently associated with a hypometabolic pattern.
REE correlated with the IL-10 but not PRISM.
In the presence of SIRS or sepsis, CRP, IL-6, IL-10, Prognostic Inflammatory and Nutritional Index (NI), and triglycerides—but not glucose, VO2, or VCO2 increased significantly.
High IL-10 levels (P=.0000) and low measured REE (P=.0000) were independently associated with mortality (11.7%), which was higher in the hypometabolic compared to other metabolic patterns (P<.005).
Our results showed that only VO2 and VCO2, but not IL-6 or IL-10, were associated with a hypometabolic pattern which predominated the acute phase of stress, and was associated with increased mortality.
Although in SIRS or sepsis, the cytokine response was reliably reflected by increases in NI and triglycerides, it was different from the metabolic (VO2, VCO2) or glucose response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Briassoulis, George& Venkataraman, Shekhar& Thompson, Ann. 2010. Cytokines and Metabolic Patterns in Pediatric Patients with Critical Illness. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989302
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Briassoulis, George…[et al.]. Cytokines and Metabolic Patterns in Pediatric Patients with Critical Illness. Journal of Immunology Research No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-989302
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Briassoulis, George& Venkataraman, Shekhar& Thompson, Ann. Cytokines and Metabolic Patterns in Pediatric Patients with Critical Illness. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-989302
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-989302
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر