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Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages
المؤلفون المشاركون
Fabbri, M.
Mantovani, Alberto
Laskarin, G.
Allavena, P.
Chieppa, M.
Solinas, G.
Bianchi, G.
المصدر
Journal of Immunology Research
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Tumor-Associated Macrophages (TAMs) are abundantly present in the stroma of solid tumors and modulate several important biological processes, such as neoangiogenesis, cancer cell proliferation and invasion, and suppression of adaptive immune responses.
Myeloid C-type lectin receptors (CLRs) constitute a large family of transmembrane carbohydrate-binding receptors that recognize pathogens as well as endogenous glycoproteins.
Several lines of evidence demonstrate that some CLRs can inhibit the immune response.
In this study we investigated TAM-associated molecules potentially involved in their immune suppressive activity.
We found that TAMs isolated from human ovarian carcinoma samples predominantly express the CLRs Dectin-1, MDL-1, MGL, DCIR, and most abundantly the Mannose Receptor (MR).
Components of carcinomatous ascites and purified tumoral mucins (CA125 and TAG-72) bound the MR and induced its internalization.
MR engagement by tumoral mucins and by an agonist anti-MR antibody modulated cytokine production by TAM toward an immune-suppressive profile: increase of IL-10, absence of IL-12, and decrease of the Th1-attracting chemokine CCL3.
This study highlights that tumoral mucin-mediated ligation of the MR on infiltrating TAM may contribute to their immune suppressive phenotype.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Allavena, P.& Chieppa, M.& Bianchi, G.& Solinas, G.& Fabbri, M.& Laskarin, G.…[et al.]. 2010. Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-989319
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Allavena, P.…[et al.]. Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages. Journal of Immunology Research No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-989319
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Allavena, P.& Chieppa, M.& Bianchi, G.& Solinas, G.& Fabbri, M.& Laskarin, G.…[et al.]. Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-989319
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-989319
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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