NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines

الملخص EN

Active specific immunotherapy is a promising field in cancer research.

N-glycolyl (NGc) gangliosides, and particularly NGcGM3, have received attention as a privileged target for cancer therapy.

Many clinical trials have been performed with the anti-NGc-containing gangliosides anti-idiotype monoclonal antibody racotumomab (formerly known as 1E10) and the conjugated NGcGM3/VSSP vaccine for immunotherapy of melanoma, breast, and lung cancer.

The present paper examines the role of NGc-gangliosides in tumor biology as well as the available preclinical and clinical data on these vaccine products.

A brief discussion on the relevance of prioritization of cancer antigens in vaccine development is also included.