Testosterone Increases: Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet
المؤلفون المشاركون
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Estrogen (E) and testosterone (T) are important in the sexually dimorphic pattern of blood pressure (BP) development.
The goal was to examine the effects of endogenous E and exogenous T in the development of hypertension in female spontaneously hypertensive rats (SHR) on a high sodium diet.
Female SHR (N=27, 5-week) were divided into four groups: (1) control (n=8), (2) ovariectomized (OVX, n=26), (3) testosterone implants with intact ovaries (T, n=6), and (4) ovariectomized + testosterone implants (OVX+T, n=7).
T was given immediately after OVX and replaced every two weeks and they were fed a 3% NaCl diet.
BP was measured weekly and plasma norepinephrine (NE) analyzed by HPLC.
OVX+T females exhibited the greatest elevation in BP (190 ± 4.0 mmHg) compared to controls at 15 weeks of age (140 ± 3.4 mmHg, P<.001) and a pattern of hypertension development similar to that of male SHR.
Females with T treatment showed evidence of glomerulosclerosis.
In conclusion, T accelerated the development of hypertension similar to the BP pattern observed in males; the presence of ovaries attenuated the T induced increase in BP; T increased renal sodium reabsorption, and T increased glomerulosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Bei& Ely, Daniel. 2011. Testosterone Increases: Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989856
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Bei& Ely, Daniel. Testosterone Increases: Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet. Advances in Pharmacological and Pharmaceutical Sciences No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-989856
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Bei& Ely, Daniel. Testosterone Increases: Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet. Advances in Pharmacological and Pharmaceutical Sciences. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-989856
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-989856
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر