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Histone Deacetylase Inhibitors: The Epigenetic Therapeutics That Repress Hypoxia-Inducible Factors
المؤلفون المشاركون
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-04
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Histone deacetylase inhibitors (HDACIs) have been actively explored as a new generation of chemotherapeutics for cancers, generally known as epigenetic therapeutics.
Recent findings indicate that several types of HDACIs repress angiogenesis, a process essential for tumor metabolism and progression.
Accumulating evidence supports that this repression is mediated by disrupting the function of hypoxia-inducible factors (HIF-1, HIF-2, and collectively, HIF), which are the master regulators of angiogenesis and cellular adaptation to hypoxia.
Since HIF also regulate glucose metabolism, cell survival, microenvironment remodeling, and other alterations commonly required for tumor progression, they are considered as novel targets for cancer chemotherapy.
Though the precise biochemical mechanism underlying the HDACI-triggered repression of HIF function remains unclear, potential cellular factors that may link the inhibition of deacetylase activity to the repression of HIF function have been proposed.
Here we review published data that inhibitors of type I/II HDACs repress HIF function by either reducing functional HIF-1α levels, or repressing HIF-α transactivation activity.
In addition, underlying mechanisms and potential proteins involved in the repression will be discussed.
A thorough understanding of HDACI-induced repression of HIF function may facilitate the development of future therapies to either repress or promote angiogenesis for cancer or chronic ischemic disorders, respectively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Shuyang& Sang, Nianli. 2010. Histone Deacetylase Inhibitors: The Epigenetic Therapeutics That Repress Hypoxia-Inducible Factors. BioMed Research International،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-989913
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Shuyang& Sang, Nianli. Histone Deacetylase Inhibitors: The Epigenetic Therapeutics That Repress Hypoxia-Inducible Factors. BioMed Research International No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-989913
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Shuyang& Sang, Nianli. Histone Deacetylase Inhibitors: The Epigenetic Therapeutics That Repress Hypoxia-Inducible Factors. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-989913
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-989913
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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