Phasic and Tonic Smooth Muscle Function of the Partially Obstructed Guinea Pig Intestine

المؤلفون المشاركون

Zhao, Jingbo
Yang, Jian
Gregersen, Hans
Liao, Donghua

المصدر

BioMed Research International

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-11-21

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

This study was to generate phasic and tonic stress-strain curves for evaluation of smooth muscle function in the obstructed guinea pig jejunum.

Partial and sham obstruction of the jejunum in guinea pigs was created surgically, with guinea pigs not being operated on served as normal controls.

The animals survived 2, 4, 7, and 14 days, respectively.

The jejunal segment was distended to 10 cm H2O.

The pressure and outer diameter changes were recorded.

Passive conditions were obtained by using papaverine.

Total phasic, tonic, and passive circumferential stress and strain were computed from the diameter and pressure data with reference to the zero-stress-state geometry.

The active phasic and tonic stresses were defined as the total phasic and tonic stress minus the passive stress.

The thickness of intestinal muscle layers increased in a time-dependent manner after obstruction.

The amplitude of passive, total phasic, total tonic, active phasic, and active tonic circumferential stresses increased as function of strain 7 days after obstruction.

However, when normalized to muscle layer thickness, the amplitude of active stresses did not differ among the groups.

In conclusion, the long-term-obstructed intestine exhibits increased total smooth muscle contraction force.

However, the contraction force per smooth muscle unit did not increase.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhao, Jingbo& Liao, Donghua& Yang, Jian& Gregersen, Hans. 2011. Phasic and Tonic Smooth Muscle Function of the Partially Obstructed Guinea Pig Intestine. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990151

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhao, Jingbo…[et al.]. Phasic and Tonic Smooth Muscle Function of the Partially Obstructed Guinea Pig Intestine. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990151

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhao, Jingbo& Liao, Donghua& Yang, Jian& Gregersen, Hans. Phasic and Tonic Smooth Muscle Function of the Partially Obstructed Guinea Pig Intestine. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990151

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-990151