Transcription Factor Sp1 Is Involved in Expressional Regulation of Coxsackie and Adenovirus Receptor in Cancer Cells

المؤلفون المشاركون

Lim, Joong-Yeon
Nam, Jae-Hwan
Hwang, Ha-Young
Kim, Joo-Young
Park, Sang Ick
Park, Young Mi
Chung, Sun-Ku

المصدر

BioMed Research International

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-11-24

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Coxsackie and adenovirus receptor (CAR) was first known as a virus receptor.

Recently, it is also known to have tumor suppressive activity such as inhibition of cell proliferation, migration, and invasion.

It is important to understand how CAR expression can be regulated in cancers.

Based on an existence of putative Sp1 binding site within CAR promoter, we investigated whether indeed Sp1 is involved in the regulation of CAR expression.

We observed that deletion or mutation of Sp1 binding motif (−503/−498) prominently impaired the Sp1 binding affinity and activity of CAR promoter.

Histone deacetylase inhibitor (TSA) treatment enhanced recruitment of Sp1 to the CAR promoter in ChIP assay.

Meanwhile, Sp1 binding inhibitor suppressed the recruitment.

Exogenous expression of wild-type Sp1 increased CAR expression in CAR-negative cells; meanwhile, dominant negative Sp1 decreased the CAR expression in CAR-positive cells.

These results indicate that Sp1 is involved in regulation of CAR expression.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Chung, Sun-Ku& Kim, Joo-Young& Lim, Joong-Yeon& Park, Young Mi& Hwang, Ha-Young& Nam, Jae-Hwan…[et al.]. 2011. Transcription Factor Sp1 Is Involved in Expressional Regulation of Coxsackie and Adenovirus Receptor in Cancer Cells. BioMed Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990230

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Chung, Sun-Ku…[et al.]. Transcription Factor Sp1 Is Involved in Expressional Regulation of Coxsackie and Adenovirus Receptor in Cancer Cells. BioMed Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-990230

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Chung, Sun-Ku& Kim, Joo-Young& Lim, Joong-Yeon& Park, Young Mi& Hwang, Ha-Young& Nam, Jae-Hwan…[et al.]. Transcription Factor Sp1 Is Involved in Expressional Regulation of Coxsackie and Adenovirus Receptor in Cancer Cells. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-990230

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-990230