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Bovine Model of Doxorubicin-Induced Cardiomyopathy
المؤلفون المشاركون
Hamid, Tariq
Koenig, Steven C.
Giridharan, Guruprasad A.
Brittian, Kenneth R.
Prabhu, Sumanth D.
Bartoli, Carlo R.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-11-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Left ventricular assist devices (LVADs) constitute a recent advance in heart failure (HF) therapeutics.
As the rigorous experimental assessment of LVADs in HF requires large animal models, our objective was to develop a bovine model of cardiomyopathy.
Male calves (n=8) were used.
Four animals received 1.2 mg/kg intravenous doxorubicin weekly for seven weeks and four separate animals were studied as controls.
Doxorubicin-treated animals were followed with weekly echocardiography.
Target LV dysfunction was defined as an ejection fraction ≤35%.
Sixty days after initiating doxorubicin, a terminal study was performed to determine hemodynamic, histological, biochemical, and molecular parameters.
All four doxorubicin-treated animals exhibited significant (P<0.05) contractile dysfunction, with target LV dysfunction achieved in three animals.
Doxorubicin-treated hearts exhibited significantly reduced coronary blood flow and interstitial fibrosis and significantly increased apoptosis and myocyte size.
Gene expression of atrial natriuretic factor increased more than 3-fold.
Plasma norepinephrine and epinephrine levels were significantly increased early and late during the development of cardiomyopathy, respectively.
We conclude that sequential administration of intravenous doxorubicin in calves induces a cardiomyopathy with many phenotypic hallmarks of the failing human heart.
This clinically-relevant model may be useful for testing pathophysiologic responses to LVADs in the context of HF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bartoli, Carlo R.& Brittian, Kenneth R.& Giridharan, Guruprasad A.& Koenig, Steven C.& Hamid, Tariq& Prabhu, Sumanth D.. 2010. Bovine Model of Doxorubicin-Induced Cardiomyopathy. BioMed Research International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990277
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bartoli, Carlo R.…[et al.]. Bovine Model of Doxorubicin-Induced Cardiomyopathy. BioMed Research International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-990277
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bartoli, Carlo R.& Brittian, Kenneth R.& Giridharan, Guruprasad A.& Koenig, Steven C.& Hamid, Tariq& Prabhu, Sumanth D.. Bovine Model of Doxorubicin-Induced Cardiomyopathy. BioMed Research International. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990277
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990277
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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