Protective Effects of Rosa damascena and Its Active Constituent on Aβ(25–35)-Induced Neuritic Atrophy
المؤلفون المشاركون
Awale, Suresh
Tohda, Chihiro
Tezuka, Yasuhiro
Miyazaki, Makoto
Kadota, Shigetoshi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Dementia is a clinical syndrome characterized by multiple cognitive deficits and causes progressive neurodegeneration leading eventually to death.
The incidence of dementia is increasing worldwide with the increase in ageing population.
However, no effective treatment is available yet.
It has been hypothesized that drugs activating neurite outgrowth might induce neuronal reconstruction and help in the recovery of brain function.
Working on this hypothesis, we recently observed that the chloroform extract of the Rosa damascena significantly induced the neurite outgrowth activity and inhibited the Aβ(25–35)-induced atrophy and cell death.
Further workup led the isolation of a very long polyunsaturated fatty acid having molecular formula C37H64O2 as an active constituent.
The structure of this compound was established by extensive analysis of fragmentations observed in EI-MS mode.
The isolated compound protected Aβ(25–35)-induced atrophy and displayed strong neurite outgrowth activity.
The length of dendrite in the cells treated with this compound were comparable to those of nerve growth factor (NGF) treated cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Awale, Suresh& Tohda, Chihiro& Tezuka, Yasuhiro& Miyazaki, Makoto& Kadota, Shigetoshi. 2011. Protective Effects of Rosa damascena and Its Active Constituent on Aβ(25–35)-Induced Neuritic Atrophy. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990451
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Awale, Suresh…[et al.]. Protective Effects of Rosa damascena and Its Active Constituent on Aβ(25–35)-Induced Neuritic Atrophy. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990451
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Awale, Suresh& Tohda, Chihiro& Tezuka, Yasuhiro& Miyazaki, Makoto& Kadota, Shigetoshi. Protective Effects of Rosa damascena and Its Active Constituent on Aβ(25–35)-Induced Neuritic Atrophy. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990451
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990451
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر