Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats

المؤلفون المشاركون

Kuncová, Jitka
Mudra, Jiří
Tonar, Zbyněk
Švíglerová, Jitka
Slavíková, Jana

المصدر

Journal of Diabetes Research

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-07-17

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treated rats and respective controls aged 3 months to 2 years.

Resting bradycardia, decreased sympathetic tone, deceleration of spontaneous beating rate, and slightly declining carrier-mediated, but preserved exocytotic norepinephrine release from the atria were found in younger diabetic rats while the reactivity of the right atria to tyramine was not affected with age and disease duration.

Diabetic two-year-old animals displayed symptoms of partial spontaneous recovery including normoglycemia, increased plasma insulin concentrations, fully recovered sympathetic tone, but putative change, in releasable norepinephrine tissue stores.

Our data suggested that female diabetic heart exposed to long-lasting diabetic conditions seems to be more resistant to alteration in sympathetic innervation than the male one.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Švíglerová, Jitka& Mudra, Jiří& Tonar, Zbyněk& Slavíková, Jana& Kuncová, Jitka. 2011. Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990686

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Švíglerová, Jitka…[et al.]. Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats. Journal of Diabetes Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-990686

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Švíglerová, Jitka& Mudra, Jiří& Tonar, Zbyněk& Slavíková, Jana& Kuncová, Jitka. Alteration of the Cardiac Sympathetic Innervation Is Modulated by Duration of Diabetes in Female Rats. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990686

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-990686