Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy
المؤلفون المشاركون
Ishimura, Eiji
Nakatani, Shinya
Mori, Katsuhito
Wei, Min
Kakehashi, Anna
Yamano, Shotaro
Wanibuchi, Hideki
Inaba, Masaaki
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
To evaluate proteins associated with the development of diabetic nephropathy, a major cause of the end-stage renal disease, we analyzed protein expression in isolated glomeruli from spontaneous type 2 diabetic (OLETF) rats and their age-matched control littermates (LETO) in the early and proteinuric stages of diabetic nephropathy using QSTAR Elite LC-MS/MS.
Among the 191 and 218 proteins that were altered significantly in the OLETF rats, twenty-four were actin cytoskeleton-associated proteins implicated in the formation of stress fibers, and the impairment of actin polymerization, intermediate filaments and microtubules.
Importantly, sorbin and SH3 domain containing 2 (SORBS2), which is involved in the formation of stress fibers, was significantly upregulated in both stages of diabetic nephropathy (1.49- and 1.97-fold, resp.).
Immunohistochemical and quantitative-PCR analyses revealed upregulation of SORBS2 in podocytes of glomeruli of OLETF rats.
Our findings suggested that SORBS2 may be associated with the development of diabetic nephropathy possibility by reorganization of actin filaments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nakatani, Shinya& Kakehashi, Anna& Ishimura, Eiji& Yamano, Shotaro& Mori, Katsuhito& Wei, Min…[et al.]. 2011. Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990703
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nakatani, Shinya…[et al.]. Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy. Journal of Diabetes Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-990703
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nakatani, Shinya& Kakehashi, Anna& Ishimura, Eiji& Yamano, Shotaro& Mori, Katsuhito& Wei, Min…[et al.]. Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990703
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990703
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر