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Detection of N-Glycolyl GM3 Ganglioside in Neuroectodermal Tumors by Immunohistochemistry: An Attractive Vaccine Target for Aggressive Pediatric Cancer
المؤلفون المشاركون
Alonso, Daniel F.
Camarero, Sandra
Gabri, Mariano R.
Scursoni, Alejandra M.
Sampor, Claudia
Segatori, Valeria I.
de Dávila, María Teresa G.
Galluzzo, Laura
Lubieniecki, Fabiana
Lopez, Jessica
Chantada, Guillermo
المصدر
Journal of Immunology Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The N-glycolylated ganglioside NeuGc-GM3 has been described in solid tumors such as breast carcinoma, nonsmall cell lung cancer, and melanoma, but is usually not detected in normal human cells.
Our aim was to evaluate the presence of NeuGc-GM3 in pediatric neuroectodermal tumors by immunohistochemistry.
Twenty-seven archival cases of neuroblastoma and Ewing sarcoma family of tumors (ESFT) were analyzed.
Formalin-fixed, paraffin-embedded tumor samples were cut into 5 μm sections.
The monoclonal antibody 14F7, a mouse IgG1 that specifically recognizes NeuGc-GM3, and a peroxidase-labeled polymer conjugated to secondary antibodies were used.
Presence of NeuGc-GM3 was evident in 23 of 27 cases (85%), with an average of about 70% of positive tumors cells.
Immunoreactivity was moderate to intense in most tumors, showing a diffuse cytoplasmic and membranous staining, although cases of ESFT demonstrated a fine granular cytoplasmic pattern.
No significant differences were observed between neuroblastoma with and without NMYC oncogene amplification, suggesting that expression of NeuGc-GM3 is preserved in more aggressive cancers.
Until now, the expression of N-glycolylated gangliosides in pediatric neuroectodermal tumors has not been investigated.
The present study evidenced the expression of NeuGc-GM3 in a high proportion of neuroectodermal tumors, suggesting its potential utility as a specific target of immunotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Scursoni, Alejandra M.& Galluzzo, Laura& Camarero, Sandra& Lopez, Jessica& Lubieniecki, Fabiana& Sampor, Claudia…[et al.]. 2011. Detection of N-Glycolyl GM3 Ganglioside in Neuroectodermal Tumors by Immunohistochemistry: An Attractive Vaccine Target for Aggressive Pediatric Cancer. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990736
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Scursoni, Alejandra M.…[et al.]. Detection of N-Glycolyl GM3 Ganglioside in Neuroectodermal Tumors by Immunohistochemistry: An Attractive Vaccine Target for Aggressive Pediatric Cancer. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-990736
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Scursoni, Alejandra M.& Galluzzo, Laura& Camarero, Sandra& Lopez, Jessica& Lubieniecki, Fabiana& Sampor, Claudia…[et al.]. Detection of N-Glycolyl GM3 Ganglioside in Neuroectodermal Tumors by Immunohistochemistry: An Attractive Vaccine Target for Aggressive Pediatric Cancer. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-990736
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990736
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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