A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis
المؤلفون المشاركون
Seto, Yohei
Ikeda, Kei
Iwamoto, Itsuo
Watanabe, Norihiko
Saito, Yasushi
Matsumura, Ryutaro
Nakajima, Hiroshi
Oya, Yoshihiro
Oki, Mie
Owada, Takayoshi
المصدر
Journal of Immunology Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Inhibitory coreceptors are thought to play important roles in maintaining immunological homeostasis, and a defect in the negative signals from inhibitory coreceptors may lead to the development of autoimmune diseases.
We have recently identified B and T lymphocyte attenuator (BTLA), a new inhibitory coreceptor expressed on immune cells, and we suggest that BTLA may be involved in the development of autoimmune diseases using BTLA-deficient mice.
However, the role of BTLA in the pathogenesis of autoimmune diseases in humans remains unknown.
We, therefore, examined the possible association between BTLA and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjögren's syndrome (SS) by conducting a case-control genetic association study.
We found that 590C single-nucleotide polymorphism (SNP) of BTLA gene was significantly associated with susceptibility to RA, but not to SLE or SS.
Furthermore, RA patients bearing this 590C SNP developed the disease significantly earlier than the patients without this allele.
We also found that BTLA with 590C allele lacked the inhibitory activity on concanavalin A- and anti-CD3 Ab-induced IL-2 production in Jurkat T cells.
These results suggest that BTLA is an RA-susceptibility gene and is involved in the protection from autoimmunity in humans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oki, Mie& Watanabe, Norihiko& Owada, Takayoshi& Oya, Yoshihiro& Ikeda, Kei& Saito, Yasushi…[et al.]. 2011. A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990750
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oki, Mie…[et al.]. A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-990750
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oki, Mie& Watanabe, Norihiko& Owada, Takayoshi& Oya, Yoshihiro& Ikeda, Kei& Saito, Yasushi…[et al.]. A Functional Polymorphism in B and T Lymphocyte Attenuator Is Associated with Susceptibility to Rheumatoid Arthritis. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990750
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990750
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر