Thymic Self-Antigen Expression for the Design of a NegativeTolerogenic Self-Vaccine against Type 1 Diabetes
المؤلفون المشاركون
Geenen, Vincent
Alami Chentoufi, Aziz
المصدر
Journal of Immunology Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Before being able to react against infectious non-self-antigens, the immune system has to be educated in the recognition and tolerance of neuroendocrine proteins, and this critical process essentially takes place in the thymus.
The development of the autoimmune diabetogenic response results from a thymus dysfunction in programming central self-tolerance to pancreatic insulin-secreting islet β cells, leading to the breakdown of immune homeostasis with an enrichment of islet β cell reactive effector T cells and a deficiency of β cell-specific natural regulatory T cells (nTreg) in the peripheral T-lymphocyte repertoire.
Insulin-like growth factor 2 (IGF-2) is the dominant member of the insulin family expressed during fetal life by the thymic epithelium under the control of the autoimmune regulator (AIRE) gene/protein.
Based on the close homology and cross-tolerance between insulin, the primary T1D autoantigen, and IGF-2, the dominant self-antigen of the insulin family, a novel type of vaccination, so-called “negative/tolerogenic self-vaccination”, is currently developed for prevention and cure of T1D.
If this approach were found to be effective for reprogramming immunological tolerance in T1D, it could pave the way for the design of negative self-vaccines against autoimmune endocrine diseases, as well as other organ-specific autoimmune diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alami Chentoufi, Aziz& Geenen, Vincent. 2011. Thymic Self-Antigen Expression for the Design of a NegativeTolerogenic Self-Vaccine against Type 1 Diabetes. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990758
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alami Chentoufi, Aziz& Geenen, Vincent. Thymic Self-Antigen Expression for the Design of a NegativeTolerogenic Self-Vaccine against Type 1 Diabetes. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-990758
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alami Chentoufi, Aziz& Geenen, Vincent. Thymic Self-Antigen Expression for the Design of a NegativeTolerogenic Self-Vaccine against Type 1 Diabetes. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990758
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990758
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر