Modulation of Cytokine and Cytokine ReceptorAntagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever
المؤلفون المشاركون
Fredeking, T. M.
Castro, J. E. Z.
Perez-Osorio, C.
Vado-Solis, I.
المصدر
Journal of Immunology Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-08
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Dengue virus infection can lead to dengue fever (DF) or dengue hemorrhagic fever (DHF).
Disease severity has been linked to an increase in various cytokine levels.
In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF.
Hospitalized patients were randomized to receive standard supportive care or supportive care combined with doxycycline or tetracycline therapy.
Serum cytokine and cytokine receptor/antagonist levels were determined at the onset of therapy and after 3 and 7 days.
Cytokine and cytokine receptor/antagonist levels were substantially elevated at day 0.
IL-6, IL-1β, and TNF remained at or above day 0 levels throughout the study period in untreated patients.
Treatment with tetracycline or doxycycline resulted in a significant decline in cytokine levels.
Similarly, IL-1RA and TNF-R1 serum concentrations were elevated at baseline and showed a moderate increase among untreated patients.
Both drugs resulted in a significant rise in IL-1Ra levels by day 3 in patients.
In contrast, treatment did not affect a similar result for TNF-R1.
When compared to the control group, however, a significant rise post-treatment was seen upon intragroup analysis.
Further analysis demonstrated that doxycycline was significantly more effective at modulating cytokine and cytokine receptor/antagonist levels than tetracycline.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Castro, J. E. Z.& Vado-Solis, I.& Perez-Osorio, C.& Fredeking, T. M.. 2011. Modulation of Cytokine and Cytokine ReceptorAntagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990770
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Castro, J. E. Z.…[et al.]. Modulation of Cytokine and Cytokine ReceptorAntagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-990770
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Castro, J. E. Z.& Vado-Solis, I.& Perez-Osorio, C.& Fredeking, T. M.. Modulation of Cytokine and Cytokine ReceptorAntagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990770
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990770
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر