![](/images/graphics-bg.png)
Novel Prophylactic Vaccine Using a Prime-Boost Method and Hemagglutinating Virus of Japan-Envelope against Tuberculosis
المؤلفون المشاركون
Takao, Kyoko
Yoshida, Shigeto
Nakatani, Hitoshi
Inoue, Yoshikazu
Hashimoto, Satomi
Kishigami, Chie
Sekine, Yuki
Nakajima, Toshihiro
McMurray, David N.
Kaneda, Yasufumi
Sakatani, Mitsunori
Nishida, Yasuko
Kita, Yoko
Nagasawa, Tetsuji
Okada, Masaji
Kanamaru, Noriko
Nishimatsu, Shiho
المصدر
Journal of Immunology Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Mycobacterium tuberculosis infection is a major global threat to human health.
The only tuberculosis (TB) vaccine currently available is bacillus Calmette-Guérin (BCG), although it has no efficacy in adults.
Therefore, the development of a novel vaccine against TB for adults is desired.
Method.
A novel TB vaccine expressing mycobacterial heat shock protein 65 (HSP65) and interleukin-12 (IL-12) delivered by the hemagglutinating virus of Japan- (HVJ)- envelope was evaluated against TB infection in mice.
Bacterial load reductions and histopathological assessments were used to determine efficacy.
Results.
Vaccination by BCG prime with IgHSP65+murine IL-12/HVJ-envelope boost resulted in significant protective efficacy (>10, 000-fold versus BCG alone) against TB infection in the lungs of mice.
In addition to bacterial loads, significant protective efficacy was demonstrated by histopathological analysis of the lungs.
Furthermore, the vaccine increased the number of T cells secreting IFN-γ.
Conclusion.
This vaccine showed extremely significant protection against TB in a mouse model, consistent with results from a similar paper on cynomolgus monkeys.
The results suggest that further development of the vaccine for eventual testing in clinical trials may be warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Okada, Masaji& Kita, Yoko& Nakajima, Toshihiro& Kanamaru, Noriko& Hashimoto, Satomi& Nagasawa, Tetsuji…[et al.]. 2011. Novel Prophylactic Vaccine Using a Prime-Boost Method and Hemagglutinating Virus of Japan-Envelope against Tuberculosis. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Okada, Masaji…[et al.]. Novel Prophylactic Vaccine Using a Prime-Boost Method and Hemagglutinating Virus of Japan-Envelope against Tuberculosis. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-990808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Okada, Masaji& Kita, Yoko& Nakajima, Toshihiro& Kanamaru, Noriko& Hashimoto, Satomi& Nagasawa, Tetsuji…[et al.]. Novel Prophylactic Vaccine Using a Prime-Boost Method and Hemagglutinating Virus of Japan-Envelope against Tuberculosis. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-990808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)