HLA Class II Defects in Burkitt Lymphoma: Bryostatin-1-Induced 17 kDa Protein Restores CD4+ T-Cell Recognition
المؤلفون المشاركون
Haque, Azizul
Hossain, Azim
Radwan, Faisal F. Y.
God, Jason M.
Bethard, Jennifer R.
Zhao, Dan
Amria, Shereen
المصدر
Journal of Immunology Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
While the defects in HLA class I-mediated Ag presentation by Burkitt lymphoma (BL) have been well documented, CD4+ T-cells are also poorly stimulated by HLA class II Ag presentation, and the reasons underlying this defect(s) have not yet been fully resolved.
Here, we show that BL cells are deficient in their ability to optimally stimulate CD4+ T cells via the HLA class II pathway.
The observed defect was not associated with low levels of BL-expressed costimulatory molecules, as addition of external co-stimulation failed to result in BL-mediated CD4+ T-cell activation.
We further demonstrate that BL cells express the components of the class II pathway, and the defect was not caused by faulty Ag/class II interaction, because antigenic peptides bound with measurable affinity to BL-associated class II molecules.
Treatment of BL with broystatin-1, a potent modulator of protein kinase C, led to significant improvement of functional class II Ag presentation in BL.
The restoration of immune recognition appeared to be linked with an increased expression of a 17 kDa peptidylprolyl-like protein.
These results demonstrate the presence of a specific defect in HLA class II-mediated Ag presentation in BL and reveal that treatment with bryostatin-1 could lead to enhanced immunogenicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hossain, Azim& God, Jason M.& Radwan, Faisal F. Y.& Amria, Shereen& Zhao, Dan& Bethard, Jennifer R.…[et al.]. 2011. HLA Class II Defects in Burkitt Lymphoma: Bryostatin-1-Induced 17 kDa Protein Restores CD4+ T-Cell Recognition. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990860
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hossain, Azim…[et al.]. HLA Class II Defects in Burkitt Lymphoma: Bryostatin-1-Induced 17 kDa Protein Restores CD4+ T-Cell Recognition. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-990860
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hossain, Azim& God, Jason M.& Radwan, Faisal F. Y.& Amria, Shereen& Zhao, Dan& Bethard, Jennifer R.…[et al.]. HLA Class II Defects in Burkitt Lymphoma: Bryostatin-1-Induced 17 kDa Protein Restores CD4+ T-Cell Recognition. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990860
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990860
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر