Inflammatory Mechanisms of Neurodegeneration in Toxin-Based Models of Parkinson's Disease
المؤلفون المشاركون
Bobyn, Jessica
Mangano, Emily
Moloney, Kerry
Hayley, Shawn
Litteljohn, Darcy
Clarke, Melanie
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-19
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Parkinson's disease (PD) has been associated with exposure to a variety of environmental agents, including pesticides, heavy metals, and organic pollutants; and inflammatory processes appear to constitute a common mechanistic link among these insults.
Indeed, toxin exposure has been repeatedly demonstrated to induce the release of oxidative and inflammatory factors from immunocompetent microglia, leading to damage and death of midbrain dopamine (DA) neurons.
In particular, proinflammatory cytokines such as tumor necrosis factor-α and interferon-γ, which are produced locally within the brain by microglia, have been implicated in the loss of DA neurons in toxin-based models of PD; and mounting evidence suggests a contributory role of the inflammatory enzyme, cyclooxygenase-2.
Likewise, immune-activating bacterial and viral agents were reported to have neurodegenerative effects themselves and to augment the deleterious impact of chemical toxins upon DA neurons.
The present paper will focus upon the evidence linking microglia and their inflammatory processes to the death of DA neurons following toxin exposure.
Particular attention will be devoted to the possibility that environmental toxins can activate microglia, resulting in these cells adopting a “sensitized” state that favors the production of proinflammatory cytokines and damaging oxidative radicals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Litteljohn, Darcy& Mangano, Emily& Clarke, Melanie& Bobyn, Jessica& Moloney, Kerry& Hayley, Shawn. 2010. Inflammatory Mechanisms of Neurodegeneration in Toxin-Based Models of Parkinson's Disease. Parkinson’s Disease،Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-991096
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Litteljohn, Darcy…[et al.]. Inflammatory Mechanisms of Neurodegeneration in Toxin-Based Models of Parkinson's Disease. Parkinson’s Disease No. 2011 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-991096
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Litteljohn, Darcy& Mangano, Emily& Clarke, Melanie& Bobyn, Jessica& Moloney, Kerry& Hayley, Shawn. Inflammatory Mechanisms of Neurodegeneration in Toxin-Based Models of Parkinson's Disease. Parkinson’s Disease. 2010. Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-991096
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991096
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر