Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma
المؤلفون المشاركون
Hogg, D.
Wunder, Jay S.
O’Sullivan, B.
al-Hussaini, H.
Hopyan, S.
Blackstein, Martin E.
Gupta, A. A.
Griffin, Anthony M.
Hodgson, D.
Ferguson, Peter C.
Catton, Charles
Chung, P. W.
Kandel, Rita A.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
There remains controversy on the routine use of chemotherapy in localized SS.
Methods.
The records of 87 adult (AP) and 15 pediatric (PP) patients with localized SS diagnosed between 1986 and 2007 at 2 centres in Toronto were reviewed.
Results.
Median age for AP and PP was 37.6 (range 15–76) and 14 (range 0.4–18) years, respectively.
65 (64%) patients had large tumours (>5 cm).
All patients underwent en bloc surgical resection resulting in 94 (92.2%) negative and 8 (7.8%) microscopically positive surgical margins.
72 (82.8%) AP and 8 (53%) PP received radiotherapy.
Chemotherapy was administered to 12 (13.8%) AP and 13 (87%) PP.
10 AP and 5 PP were evaluable for response to neoadjuvant chemotherapy, with response rate of 10% and 40%, respectively.
5-year EFS and OS was 69.3±4.8% and 80.3±4.3%, respectively, and was similar for AP and PP, In patients with tumors >5 cm, in whom chemotherapy might be considered most appropriate, relapse occurred in 9/19 (47%) with chemotherapy, compared to 17/46 (37%) In those without.
Conclusions.
Patients with localized SS have a good chance of cure with surgery and RT.
Evidence for a well-defined role of chemotherapy to improve survival In localized SS remains elusive.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Hussaini, H.& Hogg, D.& Blackstein, Martin E.& O’Sullivan, B.& Catton, Charles& Chung, P. W.…[et al.]. 2011. Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma. Complexity،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-991156
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Hussaini, H.…[et al.]. Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma. Complexity No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-991156
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Hussaini, H.& Hogg, D.& Blackstein, Martin E.& O’Sullivan, B.& Catton, Charles& Chung, P. W.…[et al.]. Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma. Complexity. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-991156
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991156
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر