Human Chondrosarcoma Cells Acquire an Epithelial-Like GeneExpression Pattern via an Epigenetic Switch: Evidence forMesenchymal-Epithelial Transition during Sarcomagenesis
المؤلفون المشاركون
Provenzano, Matthew J.
Fitzgerald, Matthew P.
Gourronc, Francoise
Case, Adam J.
Domann, Frederick E.
Martin, James A.
Teoh, Melissa L. T.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Chondrocytes are mesenchymally derived cells that reportedly acquire some epithelial characteristics; however, whether this is a progression through a mesenchymal to epithelial transition (MET) during chondrosarcoma development is still a matter of investigation.
We observed that chondrosarcoma cells acquired the expression of four epithelial markers, E-cadherin,desmocollin 3, maspin, and 14-3-3σ, all of which are governed epigenetically through cytosine methylation.
Indeed, loss of cytosine methylation was tightly associated with acquired expression of both maspin and 14-3-3σ in chondrosarcomas.
In contrast, chondrocyte cells were negative for maspin and 14-3-3σ and displayed nearly complete DNA methylation.
Robust activation of these genes was also observed in chondrocyte cells following 5-aza-dC treatment.
We also examined the transcription factor snail which has been reported to be an important mediator of epithelial to mesenchymal transitions (EMTs).
In chondrosarcoma cells snail is downregulated suggesting a role for loss of snail expression in lineage maintenance.
Taken together, these results document an epigenetic switch associated with an MET-like phenomenon that accompanies chondrosarcoma progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fitzgerald, Matthew P.& Gourronc, Francoise& Teoh, Melissa L. T.& Provenzano, Matthew J.& Case, Adam J.& Martin, James A.…[et al.]. 2011. Human Chondrosarcoma Cells Acquire an Epithelial-Like GeneExpression Pattern via an Epigenetic Switch: Evidence forMesenchymal-Epithelial Transition during Sarcomagenesis. Complexity،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-991202
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fitzgerald, Matthew P.…[et al.]. Human Chondrosarcoma Cells Acquire an Epithelial-Like GeneExpression Pattern via an Epigenetic Switch: Evidence forMesenchymal-Epithelial Transition during Sarcomagenesis. Complexity No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-991202
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fitzgerald, Matthew P.& Gourronc, Francoise& Teoh, Melissa L. T.& Provenzano, Matthew J.& Case, Adam J.& Martin, James A.…[et al.]. Human Chondrosarcoma Cells Acquire an Epithelial-Like GeneExpression Pattern via an Epigenetic Switch: Evidence forMesenchymal-Epithelial Transition during Sarcomagenesis. Complexity. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-991202
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991202
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر