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Protective Effects of Methylsulfonylmethane on Hemodynamics and Oxidative Stress in Monocrotaline-Induced Pulmonary Hypertensive Rats
المؤلفون المشاركون
Bohlooli, Shahab
Garjani, Alireza
Darabi, Masoud
Maleki-Dizaji, Nasrin
Sadeghi-Bazargani, Homayon
Hamzeiy, Hossein
Mohammadi, Sadollah
Mostafalou, Sara
Najafi, Moslem
Pezeshkian, Masoud
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-15
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Methylsulfonylmethane (MSM) is naturally occurring organic sulfur that is known as a potent antioxidant/anti-inflammatory compound.
The aim of this study was to investigate the effect of MSM on hemodynamics functions and oxidative stress in rats with monocrotaline- (MCT-) induced pulmonary arterial hypertension (PAH).
Wistar rats were randomly assigned to 38-days treatment.
MSM was administered to rats at 100, 200, and 400 mg/kg/day doses 10 days before a single dose of 60 mg/kg, IP, MCT.
Hemodynamics of ventricles were determined by Powerlab AD instrument.
Blood samples were obtained to evaluate changes in the antioxidative system including activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and the level of reduced glutathione (GSH) and malondialdehyde (MDA).
Improvements in cardiopulmonary hemodynamics were observed in the MSM-treated pulmonary arterial hypertensive rats, with a significant reduction in right ventricular systolic pressure (RSVP) and an increase in the mean arterial pressure (MAP).
The values of CAT, SOD, GSH-px activities, and GSH were significantly lower in MCT-induced PAH (P<0.01), but they were recovered to control levels of MSM-treated groups.
Our present results suggest that long-term administration of the MSM attenuates MCT-induced PAH in rats through modulation of oxidative stress and antioxidant defense.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohammadi, Sadollah& Najafi, Moslem& Hamzeiy, Hossein& Maleki-Dizaji, Nasrin& Pezeshkian, Masoud& Sadeghi-Bazargani, Homayon…[et al.]. 2012. Protective Effects of Methylsulfonylmethane on Hemodynamics and Oxidative Stress in Monocrotaline-Induced Pulmonary Hypertensive Rats. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991429
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohammadi, Sadollah…[et al.]. Protective Effects of Methylsulfonylmethane on Hemodynamics and Oxidative Stress in Monocrotaline-Induced Pulmonary Hypertensive Rats. Advances in Pharmacological and Pharmaceutical Sciences No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-991429
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohammadi, Sadollah& Najafi, Moslem& Hamzeiy, Hossein& Maleki-Dizaji, Nasrin& Pezeshkian, Masoud& Sadeghi-Bazargani, Homayon…[et al.]. Protective Effects of Methylsulfonylmethane on Hemodynamics and Oxidative Stress in Monocrotaline-Induced Pulmonary Hypertensive Rats. Advances in Pharmacological and Pharmaceutical Sciences. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991429
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991429
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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