Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development: A Clinician’s Request for a More Integrated Approach
المؤلفون المشاركون
van den Anker, Johannes N.
Allegaert, Karel
Smits, Anne
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-05
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
With great interest we read the paper of Khalil and Läer on the concepts of physiologically based pharmacokinetic (PBPK) modeling and its applications to pediatric drug development [1].
The authors clearly described the methodology, applications, and limitations of PBPK models in pediatric drug development [1].
In essence, PBPK models hold the promise to design and perform a pediatric study based on “a well-educated guess” to paraphrase what the authors refer to as “confirmatory” instead of “exploratory” approach.
The approach described by the authors hereby mainly reflects what we would like to describe as a “top-down (from model to clinical observations)” concept: based on the available knowledge on developmental anatomy and physiology, a PBPK model is developed, undergoes validation, and will subsequently facilitate pediatric studies [1].
We would like to further challenge research groups active in the field of PBPK modeling not to get too disconnected from the “in vivo” world of pediatric developmental pharmacology and also consider what we would like to describe as a “bottom-up (from clinical observations to model)” concept: from compound specific observations to mechanism-based models [2–5].
It is our strong opinion that active comparison between PBPK and mechanism based models using the same in vivo datasets can be helpful to further improve clinical care but also provides guidance for more focused studies on aspects of developmental physiology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Allegaert, Karel& Smits, Anne& van den Anker, Johannes N.. 2012. Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development: A Clinician’s Request for a More Integrated Approach. BioMed Research International،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-991449
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Allegaert, Karel…[et al.]. Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development: A Clinician’s Request for a More Integrated Approach. BioMed Research International No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-991449
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Allegaert, Karel& Smits, Anne& van den Anker, Johannes N.. Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development: A Clinician’s Request for a More Integrated Approach. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-991449
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991449
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر