Distinct Effects of Contraction-Induced Injury In Vivo on Four Different Murine Models of Dysferlinopathy
المؤلفون المشاركون
Roche, Joseph A.
Ru, Lisa W.
Bloch, Robert J.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Mutations in the DYSF gene, encoding dysferlin, cause muscular dystrophies in man.
We compared 4 dysferlinopathic mouse strains: SJL/J and B10.SJL-Dysfim/AwaJ (B10.SJL), and A/J and B6.A-Dysfprmd/GeneJ (B6.A/J).
The former but not the latter two are overtly myopathic and weaker at 3 months of age.
Following repetitive large-strain injury (LSI) caused by lengthening contractions, all except B6.A/J showed ~40% loss in contractile torque.
Three days later, torque in SJL/J, B10.SJL and controls, but not A/J, recovered nearly completely.
B6.A/J showed ~30% torque loss post-LSI and more variable recovery.
Pre-injury, all dysferlinopathic strains had more centrally nucleated fibers (CNFs) and all but A/J showed more inflammation than controls.
At D3, all dysferlinopathic strains showed increased necrosis and inflammation, but not more CNFs; controls were unchanged.
Dystrophin-null DMDmdx mice showed more necrosis and inflammation than all dysferlin-nulls.
Torque loss and inflammation on D3 across all strains were linearly related to necrosis.
Our results suggest that (1) dysferlin is not required for functional recovery 3 days after LSI; (2) B6.A/J mice recover from LSI erratically; (3) SJL/J and B10.SJL muscles recover rapidly, perhaps due to ongoing myopathy; (4) although they recover function to different levels, all 4 dysferlinopathic strains show increased inflammation and necrosis 3 days after LSI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Roche, Joseph A.& Ru, Lisa W.& Bloch, Robert J.. 2012. Distinct Effects of Contraction-Induced Injury In Vivo on Four Different Murine Models of Dysferlinopathy. BioMed Research International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-991462
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Roche, Joseph A.…[et al.]. Distinct Effects of Contraction-Induced Injury In Vivo on Four Different Murine Models of Dysferlinopathy. BioMed Research International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-991462
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Roche, Joseph A.& Ru, Lisa W.& Bloch, Robert J.. Distinct Effects of Contraction-Induced Injury In Vivo on Four Different Murine Models of Dysferlinopathy. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-991462
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991462
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر