New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy
المؤلفون المشاركون
Mirzayans, Razmik
Murray, David
Andrais, Bonnie
Scott, April
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-15
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Activation of the p53 signaling pathway by DNA-damaging agents was originally proposed to result either in cell cycle checkpoint activation to promote survival or in apoptotic cell death.
This model provided the impetus for numerous studies focusing on the development of p53-based cancer therapies.
According to recent evidence, however, most p53 wild-type human cell types respond to ionizing radiation by undergoing stress-induced premature senescence (SIPS) and not apoptosis.
SIPS is a sustained growth-arrested state in which cells remain viable and secrete factors that may promote cancer growth and progression.
The p21WAF1 (hereafter p21) protein has emerged as a key player in the p53 pathway.
In addition to its well-studied role in cell cycle checkpoints, p21 regulates p53 and its upstream kinase (ATM), controls gene expression, suppresses apoptosis, and induces SIPS.
Herein, we review these and related findings with human solid tumor-derived cell lines, report new data demonstrating dynamic behaviors of p53 and p21 in the DNA damage response, and examine the gain-of-function properties of cancer-associated p53 mutations.
We point out obstacles in cancer-therapeutic strategies that are aimed at reactivating the wild-type p53 function and highlight some alternative approaches that target the apoptotic threshold in cancer cells with differing p53 status.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mirzayans, Razmik& Andrais, Bonnie& Scott, April& Murray, David. 2012. New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy. BioMed Research International،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-991479
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mirzayans, Razmik…[et al.]. New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy. BioMed Research International No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-991479
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mirzayans, Razmik& Andrais, Bonnie& Scott, April& Murray, David. New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-991479
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991479
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر