The CD39-Adenosinergic Axis in the Pathogenesis of Immune and Nonimmune Diabetes

الملخص EN

Diabetes mellitus encompasses two distinct disease processes: autoimmune Type 1 (T1D) and nonimmune Type 2 (T2D) diabetes.

Despite the disparate aetiologies, the disease phenotype of hyperglycemia and the associated complications are similar.

In this paper, we discuss the role of the CD39-adenosinergic axis in the pathogenesis of both T1D and T2D, with particular emphasis on the role of CD39 and CD73.