Investigation of Antimicrobial Activity and Statistical Optimization of Bacillus subtilis SPB1 Biosurfactant Production in Solid-State Fermentation
المؤلفون المشاركون
Saadaoui, Imen
Ayadi, Imen
Maktouf, Sameh
Chaabouni-Ellouze, Semia
Mnif, Ines
Chaabouni-Ellouze, Semia
Kammoun, Radhouan
Abdelkefi-Mesrati, Lobna
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
During the last years, several applications of biosurfactants with medical purposes have been reported.
Biosurfactants are considered relevant molecules for applications in combating many diseases.
However, their use is currently extremely limited due to their high cost in relation to that of chemical surfactants.
Use of inexpensive substrates can drastically decrease its production cost.
Here, twelve solid substrates were screened for the production of Bacillus subtilis SPB1 biosurfactant and the maximum yield was found with millet.
A Plackett-Burman design was then used to evaluate the effects of five variables (temperature, moisture, initial pH, inoculum age, and inoculum size).
Statistical analyses showed that temperature, inoculum age, and moisture content had significantly positive effect on SPB1 biosurfactant production.
Their values were further optimized using a central composite design and a response surface methodology.
The optimal conditions of temperature, inoculum age, and moisture content obtained under the conditions of study were 37°C, 14 h, and 88%, respectively.
The evaluation of the antimicrobial activity of this compound was carried out against 11 bacteria and 8 fungi.
The results demonstrated that this biosurfactant exhibited an important antimicrobial activity against microorganisms with multidrug-resistant profiles.
Its activity was very effective against Staphylococcus aureus, Staphylococcus xylosus, Enterococcus faecalis, Klebsiella pneumonia, and so forth.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chaabouni-Ellouze, Semia& Abdelkefi-Mesrati, Lobna& Mnif, Ines& Kammoun, Radhouan& Ayadi, Imen& Saadaoui, Imen…[et al.]. 2012. Investigation of Antimicrobial Activity and Statistical Optimization of Bacillus subtilis SPB1 Biosurfactant Production in Solid-State Fermentation. BioMed Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-991665
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chaabouni-Ellouze, Semia…[et al.]. Investigation of Antimicrobial Activity and Statistical Optimization of Bacillus subtilis SPB1 Biosurfactant Production in Solid-State Fermentation. BioMed Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-991665
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chaabouni-Ellouze, Semia& Abdelkefi-Mesrati, Lobna& Mnif, Ines& Kammoun, Radhouan& Ayadi, Imen& Saadaoui, Imen…[et al.]. Investigation of Antimicrobial Activity and Statistical Optimization of Bacillus subtilis SPB1 Biosurfactant Production in Solid-State Fermentation. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-991665
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991665
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر