In Silico Biology of H1N1: Molecular Modelling of Novel Receptors and Docking Studies of Inhibitors to Reveal New Insight in Flu Treatment
المؤلفون المشاركون
Behera, Deepak Kumar
Padhi, Payodhar
Behera, Pabitra Mohan
Dixit, Anshuman
Acharya, Laxmikanta
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Influenza is an infectious disease caused by RNA viruses of the family Orthomyxoviridae.
The new influenza H1N1 viral stain has emerged by the genetic combination of genes from human, pig, and bird’s H1N1 virus.
The influenza virus is roughly spherical and is enveloped by a lipid membrane.
There are two glycoproteins in this lipid membrane; namely, hemagglutinin (HA) which helps in attachment of the viral strain on the host cell surface and neuraminidase (NA) that is responsible for initiation of viral infection.
We have developed homology models of both Hemagglutinin and Neuraminidase receptors from H1N1 strains in eastern India.
The docking studies of B-Sialic acid and O-Sialic acid in the optimized and energy-minimized homology models show important H-bonding interactions with ALA142, ASP230, GLN231, GLU232, and THR141.
This information can be used for structure-based and pharmacophore-based new drug design.
We have also calculated ADME properties (Human Oral Absorption (HOA) and % HOA) for Oseltamivir which have been subject of debate for long.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Behera, Deepak Kumar& Behera, Pabitra Mohan& Acharya, Laxmikanta& Dixit, Anshuman& Padhi, Payodhar. 2012. In Silico Biology of H1N1: Molecular Modelling of Novel Receptors and Docking Studies of Inhibitors to Reveal New Insight in Flu Treatment. BioMed Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991849
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Behera, Deepak Kumar…[et al.]. In Silico Biology of H1N1: Molecular Modelling of Novel Receptors and Docking Studies of Inhibitors to Reveal New Insight in Flu Treatment. BioMed Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-991849
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Behera, Deepak Kumar& Behera, Pabitra Mohan& Acharya, Laxmikanta& Dixit, Anshuman& Padhi, Payodhar. In Silico Biology of H1N1: Molecular Modelling of Novel Receptors and Docking Studies of Inhibitors to Reveal New Insight in Flu Treatment. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-991849
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991849
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر