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In Vitro Schistosomicidal Activity of Some Brazilian Cerrado Species and Their Isolated Compounds
المؤلفون المشاركون
Cunha, Nayanne Larissa
Uchôa, Camila Jacintho de Mendonça
Cintra, Lucas Silva
Souza, Herbert Cristian de
Peixoto, Juliana Andrade
Silva, Claudia Peres
Magalhães, Lizandra Guidi
Gimenez, Valéria Maria Meleiro
Groppo, Milton
Rodrigues, Vanderlei
da Silva Filho, Ademar Alves
Andrade e Silva, Márcio Luís
Cunha, Wilson Roberto
Pauletti, Patrícia Mendonça
Januário, Ana Helena
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Miconia langsdorffii Cogn.
(Melastomataceae), Roupala montana Aubl.
(Proteaceae), Struthanthus syringifolius (Mart.) (Loranthaceae), and Schefflera vinosa (Cham.
& Schltdl.) Frodin (Araliaceae) are plant species from the Brazilian Cerrado whose schistosomicidal potential has not yet been described.
The crude extracts, fractions, the triterpenes betulin, oleanolic acid, ursolic acid and the flavonoids quercetin 3-O-β-D-rhamnoside, quercetin 3-O-β-D-glucoside, quercetin 3-O-β-D-glucopyranosyl-(1-2)-α-L-rhamnopyranoside and isorhamnetin 3-O-β-D-glucopyranosyl-(1-2)-α-L-rhamnopyranoside were evaluated in vitro against Schistosoma mansoni adult worms and the bioactive n-hexane fractions of the mentioned species were also analyzed by GC-MS.
Betulin was able to cause worm death percentage values of 25% after 120 h (at 100 μM), and 25% and 50% after 24 and 120 h (at 200 μM), respectively; besides the flavonoid quercetin 3-O-β-D-rhamnoside promoted 25% of death of the parasites at 100 μM.
Farther the flavonoids quercetin 3-O-β-D-glucoside and quercetin 3-O-β-D-rhamnoside at 100 μM exhibited significantly reduction in motor activity, 75% and 87.5%, respectively.
Biological results indicated that crude extracts of R.
montana, S.
vinosa, and M.
langsdorffii and some n-hexane and EtOAc fractions of this species were able to induce worm death to some extent.
The results suggest that lupane-type triterpenes and flavonoid monoglycosides should be considered for further antiparasites studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cunha, Nayanne Larissa& Uchôa, Camila Jacintho de Mendonça& Cintra, Lucas Silva& Souza, Herbert Cristian de& Peixoto, Juliana Andrade& Silva, Claudia Peres…[et al.]. 2012. In Vitro Schistosomicidal Activity of Some Brazilian Cerrado Species and Their Isolated Compounds. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992081
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cunha, Nayanne Larissa…[et al.]. In Vitro Schistosomicidal Activity of Some Brazilian Cerrado Species and Their Isolated Compounds. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-992081
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cunha, Nayanne Larissa& Uchôa, Camila Jacintho de Mendonça& Cintra, Lucas Silva& Souza, Herbert Cristian de& Peixoto, Juliana Andrade& Silva, Claudia Peres…[et al.]. In Vitro Schistosomicidal Activity of Some Brazilian Cerrado Species and Their Isolated Compounds. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-992081
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992081
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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