![](/images/graphics-bg.png)
Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation
المؤلفون المشاركون
Lim, Yun-Ping
Ma, Chia-Yun
Liu, Cheng-Ling
Lin, Yu-Hsien
Hu, Miao-Lin
Chen, Jih-Jung
Hung, Dong-Zong
Hsieh, Wen-Tsong
Huang, Jin-Ding
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-07
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Inconsistent expression and regulation of drug-metabolizing enzymes (DMEs) are common causes of adverse drug effects in some drugs with a narrow therapeutic index (TI).
An important cytochrome, cytochrome P450 3A4 (CYP3A4), is predominantly regulated by a nuclear receptor, pregnane X receptor (PXR).
Sesamin, a major lignan constituent in sesame seeds and oil, exhibits a variety of biological functions; however, the effect of sesamin on the modulation of CYP3A4 is not well understood.
In this study, the effects of sesamin on the PXR-CYP3A4 pathway were characterized, as well as the underlying mechanisms of those effects.
Sesamin potently attenuated CYP3A4 induction in a dose-dependent manner by blocking the activation of PXR.
The PXR inducer-mediated inhibition of CYP3A4 was further evidenced by the ability of sesamin to attenuate the effects of several PXR ligands in the CYP3A4 reporter assay.
Further mechanistic studies showed that sesamin inhibited PXR by interrupting the interacting with coregulators.
These results may lead to the development of new therapeutic and dietary approaches to reduce the frequency of inducer-drug interaction.
Sesamin was established as a novel inhibitor of PXR and may be useful for modulating DMEs expression and drug efficacies.
Modification of CYP3A4 expression and activity by consumption of sesamin may have important implications for drug safety.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lim, Yun-Ping& Ma, Chia-Yun& Liu, Cheng-Ling& Lin, Yu-Hsien& Hu, Miao-Lin& Chen, Jih-Jung…[et al.]. 2012. Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-992128
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lim, Yun-Ping…[et al.]. Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-992128
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lim, Yun-Ping& Ma, Chia-Yun& Liu, Cheng-Ling& Lin, Yu-Hsien& Hu, Miao-Lin& Chen, Jih-Jung…[et al.]. Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-992128
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992128
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)